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Details on Person UniProt:P01033 TIMP1
| Class:Id | ReferenceGeneProduct:66053 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-207 added on Sat February 7 2015 |
| _displayName | UniProt:P01033 TIMP1 |
| _timestamp | 2024-11-03 19:43:50 |
| chain | signal peptide:1-23 chain:24-207 |
| checksum | 5AE4F90FFAB2ECDC |
| comment | FUNCTION Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.SUBUNIT Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.INTERACTION Detected in rheumatoid synovial fluid (at protein level).PTM The activity of TIMP1 is dependent on the presence of disulfide bonds.PTM N-glycosylated.SIMILARITY Belongs to the protease inhibitor I35 (TIMP) family. |
| description | recommendedName: Metalloproteinase inhibitor 1 alternativeName: Erythroid-potentiating activity shortName: EPA alternativeName: Fibroblast collagenase inhibitor shortName: Collagenase inhibitor alternativeName: Tissue inhibitor of metalloproteinases 1 shortName: TIMP-1 |
| geneName | TIMP1 CLGI TIMP |
| identifier | P01033 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Growth factor Metal-binding Metalloenzyme inhibitor Metalloprotease inhibitor Phosphoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Signal Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TIMP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6785071] ENSEMBL:ENSG00000102265 TIMP1 [Homo sapiens] |
| secondaryIdentifier | TIMP1_HUMAN Q14252 Q9UCU1 |
| sequenceLength | 207 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:349743] TIMP1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:349745] TIMP1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956691] TIMP1 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8957082] p-TIMP1 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8957042] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:P01033 TIMP1 (66053)
