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Details on Person UniProt:P35590 TIE1
| Class:Id | ReferenceGeneProduct:66043 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;chain:22-1138 added on Sat February 7 2015 |
| _displayName | UniProt:P35590 TIE1 |
| _timestamp | 2025-02-21 20:15:26 |
| chain | signal peptide:1-21 chain:22-1138 |
| checksum | 3B42BE33678C58A1 |
| comment | FUNCTION Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Heterodimer with TEK/TIE2 (PubMed:20227369). Interacts with SVEP1 (via C-terminus) (PubMed:37097004).INTERACTION Specifically expressed in developing vascular endothelial cells.PTM Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. |
| description | recommendedName: Tyrosine-protein kinase receptor Tie-1 ecNumber: 2.7.10.1 |
| geneName | TIE1 TIE |
| identifier | P35590 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Angiogenesis ATP-binding Cell membrane Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Immunoglobulin domain Kinase Membrane Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TIE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957464] ENSEMBL:ENSG00000066056 TIE1 [Homo sapiens] |
| secondaryIdentifier | TIE1_HUMAN B5A949 B5A950 |
| sequenceLength | 1138 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969012] UniProt:P35590-1 TIE1 [Homo sapiens] [ReferenceIsoform:8969013] UniProt:P35590-2 TIE1 [Homo sapiens] [ReferenceIsoform:8969014] UniProt:P35590-3 TIE1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:197805] TIE1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8957419] TIE1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35590 TIE1 (66043)
