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Details on Person Diagram of Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Class:IdPathwayDiagram:660253
_displayNameDiagram of Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
_timestamp2020-07-04 15:44:26
created[InstanceEdit:660254] May, B, 2010-05-01
height1287
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1861305] May, B, 2011-10-31
[InstanceEdit:2980737] May, B, 2013-01-11
[InstanceEdit:3065681] Gillespie, ME, 2013-02-06
[InstanceEdit:3907270] Gillespie, ME, 2013-07-18
[InstanceEdit:5252148] May, B, 2014-02-05
[InstanceEdit:8952339] Jupe, Steve, 2016-12-14
[InstanceEdit:8956489] Jupe, Steve, 2017-01-23
[InstanceEdit:9034706] May, Bruce, 2018-01-10
[InstanceEdit:9693639] D'Eustachio, Peter, 2020-07-03
[InstanceEdit:9693669] D'Eustachio, Peter, 2020-07-04
representedPathway[Pathway:381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) [Homo sapiens]
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</org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="8" reactomeId="381402" position="286 254" bounds="256 244 60 21" textPosition="262 244"> <Properties> <displayName>IGFBP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="9" reactomeId="381473" position="324 401" bounds="281 390 86 22" textPosition="289 391" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IGF:IGFBP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="11" reactomeId="381475" position="1660 352" bounds="1630 340 60 25" textPosition="1636 342"> <Properties> <displayName>IGFBP6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="12" reactomeId="381482" position="1608 550" bounds="1568 539 80 22" textPosition="1573 540" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IGF:IGFBP6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="14" reactomeId="381421" position="1466 363" bounds="1435 351 62 24" textPosition="1442 352"> <Properties> <displayName>IGFBP4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="15" reactomeId="381509" position="1426 568" bounds="1387 557 79 22" textPosition="1391 558" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IGF:IGFBP4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="17" reactomeId="381512" position="409 276" bounds="380 265 58 22" textPosition="385 265"> <Properties> <displayName>IGFBP3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="18" reactomeId="381498" position="564 262" bounds="540 251 49 22" textPosition="540 251" /> <org.gk.render.RenderableComplex id="19" reactomeId="381536" position="449 458" bounds="393 447 112 22" textPosition="401 448" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IGF:IGFBP3:ALS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="21" reactomeId="381414" position="1266 399" bounds="1234 386 65 26" textPosition="1243 388"> <Properties> <displayName>IGFBP5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="22" reactomeId="381423" position="1228 624" bounds="1174 611 109 26" textPosition="1181 616" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IGF:IGFBP5:ALS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="25" reactomeId="381516" position="1505 951" bounds="1445 940 120 22" textPosition="1455 940"> <Properties> <displayName>IGFBP4(22-156)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="26" reactomeId="381510" position="1541 902" bounds="1478 891 126 22" textPosition="1487 891"> <Properties> <displayName>IGFBP4(157-237)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="30" reactomeId="381451" position="431 1268" bounds="397 1257 69 22" textPosition="409 1257" /> <org.gk.render.RenderableProtein id="31" reactomeId="381498" position="710 1129" bounds="686 1118 49 22" textPosition="686 1118"> <Properties> <displayName>IGFALS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="33" reactomeId="381415" position="1323 846" bounds="1260 834 127 24" textPosition="1273 835"> <Properties> <displayName>IGFBP5(21-163)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="34" reactomeId="381478" position="1283 899" bounds="1223 888 120 22" textPosition="1229 888"> <Properties> <displayName>IGFBP5(164-272)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="35" reactomeId="381483" position="1332 772" bounds="1282 761 100 22" textPosition="1286 761"> <Properties> <displayName>PAPPA,PAPPA2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="37" reactomeId="538718" position="75 941" bounds="16 926 118 31" textPosition="21 931"> <Properties> <displayName>IGFBP3(227-291)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="38" reactomeId="381489" position="108 1031" bounds="47 1017 122 28" textPosition="58 1020"> <Properties> <displayName>IGFBP3(28-168)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="39" reactomeId="381499" position="190 1089" bounds="123 1078 135 22" textPosition="137 1078"> <Properties> <displayName>IGFBP3(169-226)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="42" reactomeId="381534" position="302 902" bounds="241 891 122 23" textPosition="252 892"> <Properties> <displayName>IGFBP3(28-126)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="43" reactomeId="381455" position="255 832" bounds="191 821 128 22" textPosition="201 821"> <Properties> <displayName>IGFBP3(127-291)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="44" reactomeId="381470" position="291 707" bounds="263 696 57 22" textPosition="264 696"> <Properties> <displayName>MMP1,2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="47" reactomeId="381507" position="604 898" bounds="542 887 125 22" textPosition="551 887"> <Properties> <displayName>IGFBP3(125-187)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="48" reactomeId="381547" position="603 797" bounds="544 786 118 22" textPosition="553 786"> <Properties> <displayName>IGFBP3(28-124)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="49" reactomeId="381471" position="625 848" bounds="562 837 127 23" textPosition="572 838"> <Properties> <displayName>IGFBP3(188-291)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="50" reactomeId="158770" position="566 714" bounds="538 703 56 22" textPosition="540 704" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Plasmin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="54" reactomeId="381454" position="1110 834" bounds="1053 824 115 20" textPosition="1060 824"> <Properties> <displayName>IGFBP3(28-186)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="55" reactomeId="381410" position="1128 788" bounds="1066 777 125 22" textPosition="1075 777"> <Properties> <displayName>IGFBP3(291-187)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="58" reactomeId="381546" position="863 803" bounds="802 792 123 22" textPosition="810 792"> <Properties> <displayName>IGFBP3(234-291)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="59" reactomeId="381465" position="832 853" bounds="770 842 125 22" textPosition="779 842"> <Properties> <displayName>IGFBP3(125-233)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="60" reactomeId="156786" position="815 671" bounds="752 653 127 36" textPosition="755 654" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>activated thrombin (factor IIa)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="62" reactomeId="2990877" position="84 696" bounds="43 685 82 22" textPosition="45 685"> <Properties> <displayName>Cathepsin G</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="64" reactomeId="2990872" position="1088 594" bounds="1031 576 114 36" textPosition="1034 576"> <Properties> <displayName>Prostate Specific Antigen</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="79" reactomeId="8952321" position="1477 119" bounds="1415 99 124 40" textPosition="1420 104" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FAM20C:FAM20C substrates</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="83" reactomeId="8952335" position="1782 139" bounds="1722 106 120 66" textPosition="1731 109" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FAM20C:Phosphorylated FAM20C substrates</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="84" reactomeId="8931885" position="1550 173" bounds="1530 158 40 30" textPosition="1535 162"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="85" reactomeId="8931884" position="1675 177" bounds="1650 166 51 22" textPosition="1659 166"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="86" reactomeId="8957338" position="1622 75" bounds="1563 62 118 26" textPosition="1567 67" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FAM20C:FAM20A</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="87" reactomeId="17957" position="1629 140" bounds="1383 41 492 199" textPosition="1400 181" bgColor="250 240 240" lineColor="255 153 102" insets="1393 51 469 174"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="86" /> <Component id="79" /> <Component id="83" /> <Component id="65" /> <Component id="84" /> <Component id="85" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="88" reactomeId="70101" position="1632 148" bounds="1357 8 550 280" textPosition="1374 236" bgColor="250 240 240" lineColor="255 153 102" insets="1367 18 522 254"> <Components> <Component id="87" /> </Components> </org.gk.render.RenderableCompartment> </Nodes> <Edges> <org.gk.render.RenderableReaction id="1" reactomeId="381487" points="207 227, 205 291, 205 352" position="205 291" lineWidth="1.0"> <Inputs> <Input id="2" points="180 210" /> <Input id="3" points="625 145" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> <Properties> <displayName>IGFBP1 binds IGF forming IGF:IGFBP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7" reactomeId="381412" points="328 282, 327 339, 324 387" position="327 339" lineWidth="1.0"> <Inputs> <Input id="8" points="301 268" /> <Input id="3" points="633 157" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>IGFBP2 binds IGF forming IGF:IGFBP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="10" reactomeId="381503" points="1608 381, 1609 483, 1608 536" position="1609 483" lineWidth="1.0"> <Inputs> <Input id="3" points="700 147" /> <Input id="11" points="1637 368" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>IGFBP6 binds IGF forming IGF:IGFBP6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="381543" points="1425 404, 1427 486, 1426 554" position="1427 486" lineWidth="1.0"> <Inputs> <Input id="3" points="700 149" /> <Input id="14" points="1454 378" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Properties> <displayName>IGFBP4 binds IGF forming IGF:IGFBP4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="16" reactomeId="381496" points="453 300, 452 364, 449 444" position="452 364" lineWidth="1.0"> <Inputs> <Input id="3" points="646 157" /> <Input id="17" points="429 290" /> <Input id="18" points="537 270" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>Formation of the IGF:IGFBP3:ALS complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="381545" points="1219 430, 1221 505, 1227 608" position="1221 505" lineWidth="1.0"> <Inputs> <Input id="21" points="1246 415" /> <Input id="3" points="684 157" /> <Input id="18" points="592 268" /> </Inputs> <Outputs> <Output id="22" /> </Outputs> <Properties> <displayName>Formation of the IGF:IGFBP5:ALS complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="381518" points="1426 582, 1430 771, 1431 897" position="1430 771" lineWidth="1.0"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="25" points="1489 937" /> <Output id="26" points="1475 899" /> <Output id="30" points="472 1260, 1361 1071" /> </Outputs> <Catalysts> <Catalyst id="35" points="1388 771" /> </Catalysts> <Properties> <displayName>PAAP-A proteolyzes IGF:IGFBP4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="32" reactomeId="381537" points="1227 640, 1223 770, 1224 843" position="1223 770" lineWidth="1.0"> <Inputs> <Input id="22" /> </Inputs> <Outputs> <Output id="33" points="1257 844" /> <Output id="34" points="1271 885" /> <Output id="30" points="472 1259, 1146 1083" /> <Output id="31" points="729 1115" /> </Outputs> <Catalysts> <Catalyst id="35" points="1276 771" /> </Catalysts> <Properties> <displayName>PAPP-A2 proteolyzes IGF:IGFBP5:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="36" reactomeId="381500" points="438 472, 166 746, 166 939" position="166 746" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="37" points="137 939" /> <Output id="38" points="116 1014" /> <Output id="39" points="188 1075" /> <Output id="31" points="683 1120" /> <Output id="30" points="422 1251" /> </Outputs> <Catalysts> <Catalyst id="62" points="102 713" /> </Catalysts> <Properties> <displayName>Cathepsin G proteolyzes IGF:IGFBP3:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="381435" points="446 472, 396 728, 401 813" position="396 728" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="42" points="314 888" /> <Output id="43" points="322 823" /> <Output id="31" points="699 1115" /> <Output id="30" points="430 1251" /> </Outputs> <Catalysts> <Catalyst id="44" points="326 712" /> </Catalysts> <Properties> <displayName>Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="46" reactomeId="381461" points="450 472, 480 729, 484 798" position="480 729" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="47" points="590 884" /> <Output id="48" points="541 797" /> <Output id="49" points="592 834" /> <Output id="31" points="702 1115" /> <Output id="30" points="432 1251" /> </Outputs> <Catalysts> <Catalyst id="50" points="535 718" /> </Catalysts> <Properties> <displayName>Plasmin proteolyzes IGF:IGFBP-3:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="53" reactomeId="381466" points="483 472, 1031 646, 1020 787" position="1031 646" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="54" points="1090 821" /> <Output id="55" points="1063 787" /> <Output id="31" points="719 1115" /> <Output id="30" points="463 1251, 913 1107" /> </Outputs> <Catalysts> <Catalyst id="64" points="1068 618" /> </Catalysts> <Properties> <displayName>Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="381446" points="461 472, 761 725, 760 805" position="761 725" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="58" points="799 804" /> <Output id="59" points="815 839" /> <Output id="48" points="665 800" /> <Output id="31" points="711 1115" /> <Output id="30" points="438 1251" /> </Outputs> <Catalysts> <Catalyst id="60" points="797 692" /> </Catalysts> <Properties> <displayName>Thrombin proteolyzes IGF:IGFBP3:ALS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="8952289" points="1592 136, 1624 136, 1652 138" position="1624 136" lineWidth="1.0"> <Inputs> <Input id="84" stoichiometry="105" points="1567 155" /> <Input id="79" points="1542 128" /> </Inputs> <Outputs> <Output id="85" stoichiometry="105" points="1668 163" /> <Output id="83" points="1719 138" /> </Outputs> <Catalysts> <Catalyst id="79" points="1542 116, 1604 114" /> </Catalysts> <Activators> <Activator id="86" points="1622 91" /> </Activators> <Properties> <displayName>FAM20C phosphorylates FAM20C substrates</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (660253)
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