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Details on Person Diagram of Integration of energy metabolism and Defective ABCC8 can cause hypo- and hyper-glycemias
| Class:Id | PathwayDiagram:660251 |
|---|---|
| _displayName | Diagram of Integration of energy metabolism and Defective ABCC8 can cause hypo- and hyper-glycemias |
| _timestamp | 2026-04-03 20:51:35 |
| created | [InstanceEdit:660250] D'Eustachio, P, 2010-04-30 |
| height | 1921 |
| modified | [InstanceEdit:660252] D'Eustachio, P, 2010-04-30 [InstanceEdit:660257] D'Eustachio, P, 2010-05-01 [InstanceEdit:660803] D'Eustachio, P, 2010-05-01 [InstanceEdit:660804] D'Eustachio, P, 2010-05-01 [InstanceEdit:660808] D'Eustachio, P, 2010-05-01 [InstanceEdit:660810] D'Eustachio, P, 2010-05-01 [InstanceEdit:660811] D'Eustachio, P, 2010-05-01 [InstanceEdit:662886] D'Eustachio, P, 2010-05-03 [InstanceEdit:668817] D'Eustachio, P, 2010-05-04 [InstanceEdit:724541] D'Eustachio, P, 2010-05-11 [InstanceEdit:787999] D'Eustachio, P, 2010-05-22 [InstanceEdit:798935] D'Eustachio, P, 2010-05-25 [InstanceEdit:825630] D'Eustachio, P, 2010-05-26 [InstanceEdit:825633] D'Eustachio, P, 2010-05-26 [InstanceEdit:827353] Jupe, S, 2010-05-27 [InstanceEdit:833627] D'Eustachio, P, 2010-05-27 [InstanceEdit:1091701] D'Eustachio, P, 2010-11-29 [InstanceEdit:2193078] Wu, G, 2012-04-11 [InstanceEdit:2603292] D'Eustachio, P, 2012-11-19 [InstanceEdit:2984327] May, B, 2013-01-16 [InstanceEdit:3072750] D'Eustachio, P, 2013-02-06 [InstanceEdit:3074533] D'Eustachio, P, 2013-02-06 [InstanceEdit:5339583] Jassal, Bijay, 2014-03-06 [InstanceEdit:5339595] Jassal, B, 2014-03-06 [InstanceEdit:5339617] Jassal, B, 2014-03-07 [InstanceEdit:5419256] D'Eustachio, Peter, 2014-05-02 [InstanceEdit:5422859] D'Eustachio, Peter, 2014-05-05 [InstanceEdit:5672026] Jassal, Bijay, 2015-02-04 [InstanceEdit:5678400] Matthews, Lisa, 2015-02-23 [InstanceEdit:5683204] Jassal, Bijay, 2015-03-12 [InstanceEdit:5683205] Jassal, Bijay, 2015-03-12 [InstanceEdit:5683206] Jassal, Bijay, 2015-03-12 [InstanceEdit:5683248] Jassal, Bijay, 2015-03-12 [InstanceEdit:6790056] May, Bruce, 2015-08-06 [InstanceEdit:8849017] Jassal, Bijay, 2015-12-11 [InstanceEdit:8849018] Jassal, Bijay, 2015-12-11 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8951480] May, Bruce, 2016-12-06 [InstanceEdit:9029372] Jupe, Steve, 2017-11-16 [InstanceEdit:9632754] Jassal, Bijay, 2018-12-21 [InstanceEdit:9632885] May, Bruce, 2018-12-22 [InstanceEdit:9632886] May, Bruce, 2018-12-22 [InstanceEdit:9644854] Jassal, Bijay, 2019-04-25 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9645176] D'Eustachio, Peter, 2019-05-06 [InstanceEdit:9650996] Jassal, Bijay, 2019-06-25 [InstanceEdit:9652540] Jassal, Bijay, 2019-07-01 [InstanceEdit:9666707] Jassal, Bijay, 2019-11-06 [InstanceEdit:9690266] Jassal, Bijay, 2020-05-28 [InstanceEdit:9694015] Jassal, Bijay, 2020-07-08 [InstanceEdit:9728744] Jassal, Bijay, 2021-04-21 [InstanceEdit:9728887] Jassal, Bijay, 2021-04-22 [InstanceEdit:9732533] Jassal, Bijay, 2021-05-27 [InstanceEdit:9732560] Jassal, Bijay, 2021-05-27 [InstanceEdit:9748649] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9748710] D'Eustachio, Peter, 2021-07-26 [InstanceEdit:9763798] D'Eustachio, Peter, 2022-02-04 [InstanceEdit:9774112] D'Eustachio, Peter, 2022-05-16 [InstanceEdit:9820628] D'Eustachio, Peter, 2022-11-17 [InstanceEdit:9856494] D'Eustachio, Peter, 2023-12-18 [InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19 [InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20 [InstanceEdit:9857008] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9857012] D'Eustachio, Peter, 2023-12-29 [InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02 [InstanceEdit:9857135] D'Eustachio, Peter, 2024-01-02 [InstanceEdit:9857279] D'Eustachio, Peter, 2024-01-03 [InstanceEdit:9857282] D'Eustachio, Peter, 2024-01-03 [InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09 [InstanceEdit:9860885] D'Eustachio, Peter, 2024-02-11 [InstanceEdit:9861384] D'Eustachio, Peter, 2024-02-19 [InstanceEdit:9861390] D'Eustachio, Peter, 2024-02-19 [InstanceEdit:9861401] D'Eustachio, Peter, 2024-02-19 [InstanceEdit:9946420] D'Eustachio, Peter, 2025-04-24 [InstanceEdit:9946538] D'Eustachio, Peter, 2025-04-25 [InstanceEdit:9946792] D'Eustachio, Peter, 2025-04-28 [InstanceEdit:9946988] D'Eustachio, Peter, 2025-04-29 [InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30 [InstanceEdit:9947449] D'Eustachio, Peter, 2025-05-05 [InstanceEdit:9947656] D'Eustachio, Peter, 2025-05-09 [InstanceEdit:9947660] D'Eustachio, Peter, 2025-05-09 [InstanceEdit:9948440] D'Eustachio, Peter, 2025-05-20 [InstanceEdit:9949562] D'Eustachio, Peter, 2025-05-22 [InstanceEdit:9953533] D'Eustachio, Peter, 2025-06-03 [InstanceEdit:9961000] D'Eustachio, Peter, 2025-07-18 [InstanceEdit:9985740] D'Eustachio, Peter, 2026-03-25 [InstanceEdit:9986687] D'Eustachio, Peter, 2026-04-03 |
| representedPathway | [Pathway:163685] Integration of energy metabolism [Homo sapiens] [Pathway:5683177] Defective ABCC8 can cause hypo- and hyper-glycemias [Homo sapiens] |
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bgColor="204 255 255"> <Properties> <displayName>Ca-channel (closed)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="241" reactomeId="111873" position="2601 1311" bounds="2543 1300 116 23" textPosition="2543 1300" bgColor="204 255 255"> <Properties> <displayName>Ca-channel (open)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="244" reactomeId="381702" position="1701 182" bounds="1651 164 101 37" textPosition="1651 165" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RAPGEF3:cAMP complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="248" reactomeId="381680" position="1957 180" bounds="1907 162 101 37" textPosition="1907 163" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RAPGEF4:cAMP Complex</displayName> </Properties> </org.gk.render.RenderableComplex> 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<displayName>KCNJ11:ATP tetramer:ABCC8 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="274" reactomeId="74112" position="3215 1106" bounds="3190 1091 50 31" textPosition="3194 1095" /> <org.gk.render.RenderableChemical id="275" reactomeId="74016" position="2679 1107" bounds="2654 1092 50 31" textPosition="2658 1096"> <Properties> <displayName>Ca2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="276" reactomeId="265569" position="3131 1035" bounds="3066 1010 130 51" textPosition="3066 1010" bgColor="204 255 255"> <Properties> <displayName>Voltage-gated Calcium Channels (pancreatic beta cell)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableCompartment id="277" reactomeId="216798" position="2920 794" bounds="2795 641 250 307" textPosition="2806 899" bgColor="250 240 240" lineColor="255 153 102" insets="2803 652 232 284"> <Properties> <displayName>secretory granule</displayName> </Properties> <Components> <Component id="291" /> <Component id="689" /> <Component id="690" /> <Component id="1905" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="279" reactomeId="17957" position="2466 1251" bounds="2327 1105 278 293" textPosition="2342 1276" bgColor="250 240 240" lineColor="255 153 102" insets="2339 1111 256 277"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="283" /> <Component id="286" /> <Component id="285" /> <Component id="280" /> <Component id="135" /> <Component id="240" /> <Component id="239" /> <Component id="241" /> <Component id="2082" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="283" reactomeId="169696" position="2506 1391" bounds="2456 1373 101 37" textPosition="2456 1374" bgColor="204 255 255" hideComponents="true"> <Properties> 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</org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="298" reactomeId="387383" position="3131 708" bounds="3090 690 82 37" textPosition="3090 691" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Core SNARE Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="305" reactomeId="163626" position="151 706" bounds="110 695 82 23" textPosition="110 695"> <Properties> <displayName>GCG(53-81)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="306" reactomeId="163627" position="227 609" bounds="167 598 120 23" textPosition="167 599" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GCGR:GCG(53-81)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="309" reactomeId="164384" position="233 557" bounds="171 539 124 37" textPosition="171 540" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>G-protein with G(s) alpha:GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="310" reactomeId="164386" position="225 479" bounds="166 461 118 37" textPosition="166 462" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>G-beta:G-gamma dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="312" reactomeId="29438" position="380 571" bounds="360 556 41 31" textPosition="364 560" /> <org.gk.render.RenderableChemical id="314" reactomeId="29420" position="386 419" bounds="365 404 42 31" textPosition="369 408" /> <org.gk.render.RenderableChemical id="326" reactomeId="70115" position="3188 454" bounds="3171 439 35 31" textPosition="3175 443"> <Properties> <displayName>Glc</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="327" reactomeId="70113" position="3009 455" bounds="2992 440 35 31" textPosition="2996 444" /> <org.gk.render.RenderableEntitySet id="328" reactomeId="500048" position="3131 512" bounds="3101 501 60 23" textPosition="3101 501" bgColor="204 255 255"> <Properties> <displayName>GLUT1,2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="333" reactomeId="163622" position="521 176" bounds="466 158 111 37" textPosition="466 159" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>G alpha (s):GTP:Adenylate cyclase</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="340" reactomeId="111923" position="1110 462" bounds="1044 444 133 37" textPosition="1044 445" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>cAMP:PKA regulatory subunit</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="341" reactomeId="399994" position="3130 1638" bounds="3104 1627 52 23" textPosition="3104 1627"> <Properties> <displayName>CHRM3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="342" reactomeId="400013" position="3089 1776" bounds="3046 1737 87 79" textPosition="3046 1738" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="343" reactomeId="399992" position="3124 1481" bounds="3061 1456 127 51" textPosition="3061 1457" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="344" reactomeId="400441" position="3131 1288" bounds="3109 1277 45 23" textPosition="3109 1277"> <Properties> <displayName>FFAR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="345" reactomeId="400420" position="3131 1396" bounds="3066 1385 130 23" textPosition="3066 1386" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FFAR1:FFAR1 ligands</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="347" reactomeId="29438" position="3085 1529" bounds="3065 1514 41 31" textPosition="3069 1518" /> <org.gk.render.RenderableChemical id="349" reactomeId="29420" position="3086 1580" bounds="3065 1565 42 31" textPosition="3069 1569" /> <org.gk.render.RenderableComplex id="364" reactomeId="170665" position="234 180" bounds="177 162 115 37" textPosition="177 163" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Adenylate cyclase (Mg2+ cofactor)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="399" reactomeId="29512" position="492 1025" bounds="463 1010 58 31" textPosition="467 1014"> <Properties> <displayName>Fru(6)P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="400" reactomeId="29878" position="491 1081" bounds="472 1066 39 31" textPosition="476 1070"> <Properties> <displayName>E4P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="401" reactomeId="29882" position="682 1085" bounds="659 1070 47 31" textPosition="663 1074"> <Properties> <displayName>SH7P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="402" reactomeId="29578" position="685 1027" bounds="661 1012 49 31" textPosition="665 1016"> <Properties> <displayName>GA3P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="411" reactomeId="71322" position="596 940" bounds="561 929 71 23" textPosition="561 930" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TKT dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="413" reactomeId="73578" position="669 883" bounds="649 868 40 31" textPosition="653 872"> <Properties> <displayName>R5P</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="591" reactomeId="179856" position="2228 1763" bounds="2193 1748 70 31" textPosition="2197 1752"> <Properties> <displayName>PI(4,5)P2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="592" reactomeId="29356" position="2223 1708" bounds="2202 1693 43 31" textPosition="2206 1697" /> <org.gk.render.RenderableProtein id="593" reactomeId="2980862" position="3128 637" bounds="3102 626 53 23" textPosition="3102 626"> <Properties> <displayName>STXBP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="594" reactomeId="3008670" position="1539 182" bounds="1508 171 62 23" textPosition="1508 171"> <Properties> <displayName>RAPGEF3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="595" reactomeId="3008666" position="1808 181" bounds="1777 170 62 23" textPosition="1777 170"> <Properties> <displayName>RAPGEF4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="596" reactomeId="2029017" position="3130 757" bounds="3103 746 55 23" textPosition="3103 746"> <Properties> <displayName>SNAP25</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.22666666666666666" relativeY="0.0" label="Pa" description="Cyc" trackId="0" reactomeId="5244496" /> <org.gk.render.RenderableFeature relativeX="0.4666666666666667" relativeY="0.0" label="Pa" description="Cyc" trackId="1" reactomeId="5244508" /> <org.gk.render.RenderableFeature relativeX="0.7066666666666667" relativeY="0.0" label="Pa" description="Cyc" trackId="2" reactomeId="5244495" /> <org.gk.render.RenderableFeature 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<displayName>Insulin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="689" reactomeId="265011" position="2958 789" bounds="2926 778 65 23" textPosition="2926 778"> <Properties> <displayName>C Peptide</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="690" reactomeId="386977" position="2948 731" bounds="2891 706 115 51" textPosition="2891 707" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>6xInsulin:2xZn2+:Ca2+ (docked granule)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="691" reactomeId="265157" position="3471 710" bounds="3434 699 74 23" textPosition="3434 699"> <Properties> <displayName>INS(57-87)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="692" reactomeId="5659970" position="602 1128" bounds="555 1117 95 23" textPosition="555 1118" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TALDO1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1012" reactomeId="5226920" position="2481 1062" bounds="2427 1037 109 51" textPosition="2427 1038" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1015" reactomeId="29804" position="2608 250" bounds="2591 235 35 31" textPosition="2595 239" /> <org.gk.render.RenderableChemical id="1016" reactomeId="74126" position="2605 105" bounds="2588 90 35 31" textPosition="2592 94"> <Properties> <displayName>K+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1037" reactomeId="5683210" position="2501 178" bounds="2449 160 104 37" textPosition="2449 160" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>ABCC8 mutants (PNDM, TNDM2)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1038" reactomeId="6790050" position="3073 275" bounds="3037 264 72 23" textPosition="3037 265" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Mg2+:ADP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1192" reactomeId="8848653" position="1487 1765" bounds="1439 1747 97 37" textPosition="1439 1748" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ADIPOQ trimer:ADIPOR dimers</displayName> </Properties> <OldBounds> <Bounds id="1192" bounds="1380 1736 192 62" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1507" reactomeId="8848546" position="1342 1763" bounds="1294 1752 97 23" textPosition="1294 1752"> <Properties> <displayName>ADIPOR dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1508" reactomeId="8849004" position="1338 1841" bounds="1292 1830 93 23" textPosition="1292 1831" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ADIPOQ trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1509" reactomeId="390627" position="130 1131" bounds="97 1120 67 23" textPosition="97 1120"> <Properties> <displayName>ADR, NAd</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1510" reactomeId="8951729" position="939 512" bounds="894 494 90 37" textPosition="894 495" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PKA tetramer:4xcAMP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1616" reactomeId="113592" position="1084 677" bounds="1064 662 40 31" textPosition="1068 666" /> <org.gk.render.RenderableChemical id="1722" reactomeId="29370" position="1246 896" bounds="1226 881 41 31" textPosition="1230 885"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="1728" reactomeId="17906" position="2769 1513" bounds="2597 1474 344 79" textPosition="2674 1506" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>mitochondrial outer membrane</displayName> </Properties> <Components> <Component id="1739" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="1733" reactomeId="51645" position="3133 1157" bounds="3083 1146 100 23" textPosition="3083 1146"> <Properties> <displayName>4xPalmC-CD36</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.00995905412169884" label="Pa" description="Cyc" trackId="0" reactomeId="2187205" /> <org.gk.render.RenderableFeature relativeX="0.9893465235707827" relativeY="1.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187204" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.05965731811724451" label="Pa" description="Cyc" trackId="0" reactomeId="2187208" /> <org.gk.render.RenderableFeature relativeX="0.7556883678585852" relativeY="1.0" label="Pa" description="Cyc" trackId="0" reactomeId="2187207" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1736" reactomeId="76194" position="2954 1438" bounds="2923 1423 62 31" textPosition="2927 1427"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="1739" reactomeId="9632658" position="2828 1493" bounds="2800 1482 57 23" textPosition="2800 1482"> <Properties> <displayName>ACSL3,4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1741" reactomeId="76577" position="2701 1385" bounds="2680 1370 42 31" textPosition="2684 1374" /> <org.gk.render.RenderableComplex id="1742" reactomeId="76188" position="1554 1194" bounds="1508 1183 92 23" textPosition="1508 1184" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ACLY tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1860" reactomeId="9666703" position="1511 920" bounds="1476 882 70 52" textPosition="1476 909"> <Properties> <displayName>ACLY gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableEntitySet id="1862" reactomeId="9650988" position="2737 52" bounds="2699 41 77 23" textPosition="2699 41" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>Meglitinides</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1863" reactomeId="9650859" position="2886 175" bounds="2826 164 120 23" textPosition="2826 165" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ABCC8:Meglitinides</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1865" reactomeId="9652588" position="2956 52" bounds="2926 41 60 23" textPosition="2926 41" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>SU drugs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1866" reactomeId="9652593" position="3022 176" bounds="2971 165 103 23" textPosition="2971 166" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ABCC8:SU drugs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1895" reactomeId="9728630" position="85 1033" bounds="36 1022 98 23" textPosition="36 1022" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>GLP1R agonists</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1896" reactomeId="9728662" position="238 1066" bounds="192 1048 93 37" textPosition="192 1049" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>GLP1R:GLP1R agonists</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemicalDrug id="1898" reactomeId="9732524" position="3236 1261" bounds="3191 1246 90 31" textPosition="3195 1250" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>rosiglitazone</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="1899" reactomeId="9732526" position="3134 1237" bounds="3073 1226 122 23" textPosition="3073 1227" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>FFAR1:rosiglitazone</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1905" reactomeId="376363" position="3024 847" bounds="2999 836 50 23" textPosition="2999 836"> <Properties> <displayName>VAMP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1906" reactomeId="9820623" position="226 707" bounds="205 696 43 23" textPosition="205 696"> <Properties> <displayName>GCGR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1911" reactomeId="9606134" position="1338 887" bounds="1303 849 70 52" textPosition="1303 876"> <Properties> <displayName>PKLR gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1915" reactomeId="9856541" position="1447 960" bounds="1399 941 97 38" textPosition="1407 943" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX:PKLR gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1925" reactomeId="9856542" position="1617 998" bounds="1570 980 95 36" textPosition="1577 980" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX:ACLY gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1932" reactomeId="2393979" position="1667 922" bounds="1632 896 70 52" textPosition="1632 923"> <Properties> <displayName>FASN gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1936" reactomeId="9856543" position="1755 1001" bounds="1711 981 88 40" textPosition="1715 985" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX:FASN gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1945" reactomeId="1660609" position="1843 1194" bounds="1819 1183 49 23" textPosition="1819 1183"> <Properties> <displayName>ACACA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1946" reactomeId="9856497" position="1796 938" bounds="1756 900 81 52" textPosition="1756 927"> <Properties> <displayName>ACACA gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableGene id="1952" reactomeId="2393980" position="1942 936" bounds="1902 898 80 52" textPosition="1902 925"> <Properties> <displayName>ACACB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="1953" reactomeId="52493" position="1987 1192" bounds="1963 1181 48 23" textPosition="1963 1181"> <Properties> <displayName>ACACB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1954" reactomeId="9856545" position="2047 997" bounds="1999 978 97 38" textPosition="2007 980" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX:ACACB gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1957" reactomeId="9856540" position="1901 996" bounds="1855 977 92 38" textPosition="1861 979" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX:ACACA gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1964" reactomeId="9856495" position="2098 933" bounds="2054 895 89 52" textPosition="2054 922"> <Properties> <displayName>AGPAT1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1978" reactomeId="9856607" position="2195 1000" bounds="2151 982 89 37" textPosition="2151 983" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MLXIPL:MLX: AGPAT1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1997" reactomeId="9668967" position="1455 623" bounds="1437 608 36 31" textPosition="1441 612" /> <org.gk.render.RenderableChemical id="2002" reactomeId="70106" position="1113 855" bounds="1095 840 36 31" textPosition="1099 844" /> <org.gk.render.RenderableChemical id="2007" reactomeId="113582" position="1830 668" bounds="1810 653 41 31" textPosition="1814 657" /> <org.gk.render.RenderableChemical id="2008" reactomeId="9668967" position="1943 665" bounds="1925 650 36 31" textPosition="1929 654"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2011" reactomeId="113582" position="1716 786" bounds="1696 771 41 31" textPosition="1700 775" /> <org.gk.render.RenderableChemical id="2013" reactomeId="9668967" position="1765 793" bounds="1747 778 36 31" textPosition="1751 782" /> <org.gk.render.RenderableChemical id="2018" reactomeId="164121" position="1706 710" bounds="1685 695 42 31" textPosition="1689 699" /> <org.gk.render.RenderableEntitySet id="2020" reactomeId="111920" position="2719 1249" bounds="2655 1238 128 23" textPosition="2655 1238" /> <org.gk.render.RenderableEntitySet id="2021" reactomeId="400032" position="259 1506" bounds="217 1488 84 37" textPosition="217 1488"> <Properties> <displayName>G alpha (i,o) (candidates)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="2027" reactomeId="70106" position="2084 1685" bounds="2066 1670 36 31" textPosition="2070 1674" /> <org.gk.render.RenderableChemical id="2030" reactomeId="8954142" position="3230 1202" bounds="3200 1187 60 31" textPosition="3204 1191"> <Properties> <displayName>LCFA(-)</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2031" reactomeId="8876730" position="3029 1202" bounds="2999 1187 60 31" textPosition="3003 1191" /> <org.gk.render.RenderableChemical id="2037" reactomeId="113592" position="2946 1395" bounds="2926 1380 40 31" textPosition="2930 1384" /> <org.gk.render.RenderableChemical id="2046" reactomeId="164991" position="2667 1440" bounds="2630 1425 75 31" textPosition="2634 1429"> <Properties> <displayName>LCFA-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2052" reactomeId="111294" position="2763 1377" bounds="2746 1362 34 31" textPosition="2750 1366"> <Properties> <displayName>PPi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="2082" reactomeId="5622009" position="2395 1395" bounds="2360 1377 70 36" textPosition="2363 1377"> <Properties> <displayName>ITPR tetramers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2083" reactomeId="381729" position="2077 180" bounds="2029 162 96 37" textPosition="2029 162"> <Properties> <displayName>Epac1,2:cAMP complex</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="2090" reactomeId="113518" position="1526 522" bounds="1505 507 43 31" textPosition="1509 511" /> <org.gk.render.RenderableChemical id="2091" reactomeId="9949559" position="1637 503" bounds="1614 488 47 31" textPosition="1618 492" /> <org.gk.render.RenderableChemical id="2093" reactomeId="113518" position="1988 741" bounds="1967 726 43 31" textPosition="1971 730" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="138" reactomeId="400071" points="227 1153, 227 1176, 226 1209" position="227 1176" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="140" points="227 1131" /> <Input id="1509" points="170 1138" /> </Inputs> <Outputs> <Output id="141" /> </Outputs> <Catalysts> <Catalyst id="140" points="269 1112, 282 1112, 283 1176" /> </Catalysts> <Properties> <displayName>Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="143" reactomeId="400092" points="226 1342, 227 1366, 226 1395" position="227 1366" lineWidth="1.0"> <Inputs> <Input id="144" points="310 1308" /> <Input id="145" points="226 1308" /> </Inputs> <Outputs> <Output id="146" points="226 1428" /> <Output id="147" points="309 1427" /> </Outputs> <Catalysts> <Catalyst id="141" points="198 1238, 142 1258, 143 1315" /> </Catalysts> <Properties> <displayName>Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="148" reactomeId="400037" points="212 1471, 182 1507, 184 1531" position="182 1507" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="146" /> </Inputs> <Outputs> <Output id="149" points="234 1654" /> <Output id="150" points="238 1544" /> </Outputs> <Catalysts> <Catalyst id="2021" points="211 1506" /> </Catalysts> <Properties> <displayName>Gi,Go Heterotrimeric G-protein complex dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="400046" points="330 1766, 366 1766, 394 1766" position="366 1766" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="153" /> </Inputs> <Outputs> <Output id="154" /> </Outputs> <Catalysts> <Catalyst id="149" points="267 1697" /> </Catalysts> <Properties> <displayName>L-type Calcium Channels close in pancreatic beta cells</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="400063" points="711 1763, 747 1764, 783 1765" position="747 1764" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="156" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Catalysts> <Catalyst id="150" points="336 1566, 749 1635" /> </Catalysts> <Properties> <displayName>Low conductance potassium channels in pancreatic beta cells open in response to epinephrine</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="400097" points="1069 1736, 1102 1765, 1129 1764" position="1102 1765" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="159" points="1038 1746" /> <Input id="149" points="304 1677, 1068 1714" /> </Inputs> <Outputs> <Output id="160" /> </Outputs> <Catalysts> <Catalyst id="149" points="304 1674, 1102 1673" /> </Catalysts> <Properties> <displayName>G-beta:G-gamma inhibits Adenylate cyclase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="163" reactomeId="400012" points="3129 1683, 3129 1713, 3114 1734" position="3129 1713" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="341" points="3129 1653" /> <Input id="165" points="3165 1673" /> </Inputs> <Outputs> <Output id="342" /> </Outputs> <Catalysts> <Catalyst id="341" points="3108 1653, 3077 1666, 3078 1703" /> </Catalysts> <Properties> <displayName>Acetylcholine binds Muscarinic Acetylcholine Receptor M3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="399995" points="2982 1696, 2956 1696, 2939 1696" position="2956 1696" lineWidth="1.0"> <Inputs> <Input id="343" points="3058 1481, 3024 1481, 3022 1695" /> <Input id="171" points="2986 1684" /> </Inputs> <Outputs> <Output id="175" points="2872 1742" /> <Output id="173" points="2924 1681" /> </Outputs> <Catalysts> <Catalyst id="342" points="3043 1749" /> </Catalysts> <Properties> <displayName>Muscarinic Acetylcholine Receptor M3 activates Gq</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="400027" points="2770 1790, 2715 1809, 2660 1808" position="2715 1809" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="175" /> </Inputs> <Outputs> <Output id="176" points="2588 1783" /> <Output id="177" points="2672 1779" /> </Outputs> <Catalysts> <Catalyst id="175" points="2791 1799, 2716 1838" /> </Catalysts> <Properties> <displayName>Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="178" reactomeId="400023" points="2460 1730, 2430 1730, 2390 1744" position="2430 1730" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="176" points="2495 1745" /> <Input id="179" points="2498 1705" /> </Inputs> <Outputs> <Output id="180" /> </Outputs> <Catalysts> <Catalyst id="176" points="2476 1765, 2430 1765" /> </Catalysts> <Properties> <displayName>Gq alpha activates Phospholipase C beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="399998" points="2175 1737, 2146 1736, 2114 1735" position="2146 1736" lineWidth="1.0"> <Inputs> <Input id="591" points="2196 1745" /> <Input id="592" points="2199 1720" /> </Inputs> <Outputs> <Output id="185" points="2233 1337" /> <Output id="184" points="2081 1753" /> <Output id="2027" points="2093 1704" /> </Outputs> <Catalysts> <Catalyst id="180" points="2288 1778, 2222 1796, 2145 1795" /> </Catalysts> <Properties> <displayName>Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="187" reactomeId="400015" points="2013 1743, 1971 1742, 1928 1753" position="1971 1742" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="188" points="2008 1704" /> <Input id="184" points="2032 1753" /> </Inputs> <Outputs> <Output id="189" /> </Outputs> <Catalysts> <Catalyst id="188" points="1999 1704" /> </Catalysts> <Properties> <displayName>Diacylgycerol activates Protein kinase C, alpha type</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="399978" points="1711 1735, 1694 1735, 1675 1735" position="1694 1735" lineWidth="1.0"> <Inputs> <Input id="191" stoichiometry="4" points="1735 1715" /> <Input id="192" points="1740 1753" /> </Inputs> <Outputs> <Output id="193" stoichiometry="4" points="1647 1715" /> <Output id="194" points="1641 1752" /> </Outputs> <Catalysts> <Catalyst id="189" points="1822 1789, 1774 1805, 1696 1804" /> </Catalysts> <Properties> <displayName>Protein kinase C, alpha type phosphorylates MARCKS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="197" reactomeId="400434" points="3131 1337, 3131 1336, 3131 1382" position="3131 1336" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="198" points="3178 1337" /> <Input id="344" points="3131 1303" /> </Inputs> <Outputs> <Output id="345" /> </Outputs> <Catalysts> <Catalyst id="344" points="3144 1303, 3165 1318" /> </Catalysts> <Properties> <displayName>FFAR1 binds fatty acids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="202" reactomeId="416530" points="3129 1533, 3129 1546, 3128 1564" position="3129 1546" lineWidth="1.0"> <Inputs> <Input id="343" points="3126 1510" /> <Input id="347" points="3109 1530" /> </Inputs> <Outputs> <Output id="175" points="2884 1799, 2946 1829, 3245 1830, 3244 1645" /> <Output id="349" points="3110 1572" /> </Outputs> <Catalysts> <Catalyst id="345" points="3156 1411, 3199 1427, 3197 1546" /> </Catalysts> <Properties> <displayName>FFAR1:FFAR1 ligands activate Gq</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="381612" points="228 944, 228 943, 228 922" position="228 943" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="209" points="229 979" /> <Input id="210" points="161 961" /> </Inputs> <Outputs> <Output id="211" /> </Outputs> <Catalysts> <Catalyst id="210" points="127 961, 126 941" /> </Catalysts> <Properties> <displayName>GLP1R binds GLP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="213" reactomeId="381706" points="275 852, 276 838, 275 825" position="276 838" lineWidth="1.0"> <Inputs> <Input id="211" points="257 865" /> <Input id="216" points="306 878" /> </Inputs> <Outputs> <Output id="214" points="252 806" /> <Output id="218" points="302 803" /> </Outputs> <Catalysts> <Catalyst id="211" points="228 865, 228 837" /> </Catalysts> <Properties> <displayName>GLP1R:GLP1 activates G(s)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="422320" points="230 402, 230 379, 230 352" position="230 379" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="220" /> </Inputs> <Outputs> <Output id="149" points="231 1654, 117 1452, 15 1132, 15 717, 159 352" /> <Output id="221" points="230 320" /> </Outputs> <Catalysts> <Catalyst id="220" points="214 402, 192 378" /> </Catalysts> <Properties> <displayName>Heterotrimeric G(s) complex dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="223" reactomeId="381704" points="331 270, 347 233, 366 193" position="347 233" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="224" points="270 247" /> <Input id="221" points="263 291" /> </Inputs> <Outputs> <Output id="225" /> </Outputs> <Catalysts> <Catalyst id="221" points="283 304, 376 304, 376 234" /> </Catalysts> <Properties> <displayName>G(s):GTP activates Adenylyl cyclase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="226" reactomeId="381607" points="433 303, 465 282, 531 283" position="465 282" lineWidth="1.0"> <Inputs> <Input id="227" /> </Inputs> <Outputs> <Output id="228" points="611 286" /> <Output id="229" points="614 344" /> </Outputs> <Catalysts> <Catalyst id="225" points="390 193" /> </Catalysts> <Properties> <displayName>Activated Adenylyl cyclase synthesizes cyclic AMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="230" reactomeId="381707" points="673 233, 725 233, 755 232" position="725 233" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="228" stoichiometry="4" points="647 270" /> <Input id="231" points="665 203" /> </Inputs> <Outputs> <Output id="232" points="782 203" /> <Output id="40" stoichiometry="2" points="1044 568, 817 569" /> </Outputs> <Catalysts> <Catalyst id="231" points="683 203" /> </Catalysts> <Properties> <displayName>PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="234" reactomeId="381713" points="1072 178, 1099 178, 1141 177" position="1099 178" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="235" /> </Inputs> <Outputs> <Output id="236" /> </Outputs> <Catalysts> <Catalyst id="238" points="1098 225" /> </Catalysts> <Properties> <displayName>Potassium voltage-gated channels close in reponse to PKA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="239" reactomeId="381644" points="2601 1213, 2601 1250, 2601 1294" position="2601 1250" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="240" /> </Inputs> <Outputs> <Output id="241" /> </Outputs> <Catalysts> <Catalyst id="2020" points="2649 1249" /> </Catalysts> <Properties> <displayName>ER calcium channels open in response to activated PKA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="242" reactomeId="381668" points="1598 216, 1622 217, 1659 204" position="1622 217" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="594" points="1558 197" /> <Input id="228" points="665 287, 1579 255" /> </Inputs> <Outputs> <Output id="244" /> </Outputs> <Catalysts> <Catalyst id="594" points="1573 181, 1621 181" /> </Catalysts> <Properties> <displayName>cAMP activates EPAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="246" reactomeId="381608" points="1854 215, 1886 215, 1919 202" position="1886 215" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="595" points="1823 196" /> <Input id="228" stoichiometry="2" points="665 288, 1855 316" /> </Inputs> <Outputs> <Output id="248" /> </Outputs> <Catalysts> <Catalyst id="595" points="1842 181, 1884 181" /> </Catalysts> <Properties> <displayName>cAMP activates EPAC2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="250" reactomeId="381727" points="2255 178, 2283 178, 2309 178" position="2283 178" lineWidth="1.0"> <Inputs> <Input id="597" points="2229 178" /> <Input id="254" points="2234 202" /> </Inputs> <Outputs> <Output id="598" points="2339 178" /> <Output id="256" points="2332 202" /> </Outputs> <Catalysts> <Catalyst id="2083" points="2123 156, 2188 136" /> </Catalysts> <Properties> <displayName>RAP1A exchanges GDP for GTP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="266" reactomeId="265682" points="2853 234, 2966 234, 3005 234" position="2966 234" lineWidth="1.0"> <Inputs> <Input id="267" stoichiometry="4" points="2826 249" /> <Input id="268" points="2791 209" /> </Inputs> <Outputs> <Output id="269" points="3092 219" /> <Output id="1038" stoichiometry="4" points="3053 261" /> </Outputs> <Catalysts> <Catalyst id="268" points="2799 193" /> </Catalysts> <Inhibitors> <Inhibitor id="687" points="3194 361, 3056 328" /> </Inhibitors> <Activators> <Activator id="248" points="1990 202, 2121 270, 2816 307" /> <Activator id="244" points="1737 204, 1888 277, 2843 331" /> <Activator id="238" points="1168 246, 2879 366" /> <Activator id="327" points="3005 437" /> </Activators> <Properties> <displayName>KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="273" reactomeId="265645" points="3187 1106, 3130 1106, 2707 1106" position="3130 1106" lineWidth="1.0"> <Inputs> <Input id="274" /> </Inputs> <Outputs> <Output id="275" /> </Outputs> <Catalysts> <Catalyst id="276" points="3130 1067" /> </Catalysts> <Properties> <displayName>Calcium Influx through Voltage-gated Calcium Channels</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="280" reactomeId="169680" points="2338 1341, 2396 1341, 2465 1370" position="2396 1341" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="185" stoichiometry="4" points="2279 1326" /> <Input id="2082" points="2376 1371" /> </Inputs> <Outputs> <Output id="283" /> </Outputs> <Catalysts> <Catalyst id="2082" points="2395 1371" /> </Catalysts> <Properties> <displayName>IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="285" reactomeId="169683" points="2416 1178, 2506 1175, 2651 1116" position="2506 1175" lineWidth="1.0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="275" /> </Outputs> <Catalysts> <Catalyst id="283" points="2506 1370" /> </Catalysts> <Inhibitors> <Inhibitor id="1012" points="2486 1091" /> </Inhibitors> <Activators> <Activator id="185" points="2267 1300" /> </Activators> <Properties> <displayName>IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="287" reactomeId="265166" points="3246 836, 3321 834, 3389 837" position="3321 834" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="689" points="2994 794" /> <Input id="690" points="3009 751" /> <Input id="291" points="3051 888" /> <Input id="596" points="3146 772" /> <Input id="1905" points="3052 845" /> <Input id="275" stoichiometry="3" points="2707 1099, 3193 961" /> <Input id="288" points="3147 912" /> </Inputs> <Outputs> <Output id="691" points="3463 725" /> <Output id="294" points="3147 594" /> <Output id="687" stoichiometry="2" points="3226 386" /> <Output id="688" stoichiometry="6" points="3427 663" /> <Output id="593" points="3143 652" /> <Output id="274" stoichiometry="4" points="3225 1088" /> </Outputs> <Catalysts> <Catalyst id="298" points="3158 730" /> </Catalysts> <Inhibitors> <Inhibitor id="150" points="223 1560, 144 1565, 144 1905, 3487 1913, 3490 1149" /> <Inhibitor id="157" points="891 1798, 1015 1868, 3450 1870, 3451 1148" /> <Inhibitor id="154" points="505 1798, 686 1892, 3469 1889, 3470 1149" /> </Inhibitors> <Properties> <displayName>Exocytosis of Insulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="325" reactomeId="499981" points="3168 454, 3131 454, 3030 454" position="3131 454" lineWidth="1.0"> <Inputs> <Input id="326" /> </Inputs> <Outputs> <Output id="327" /> </Outputs> <Catalysts> <Catalyst id="328" points="3131 495" /> </Catalysts> <Properties> <displayName>Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="588" points="1072 177, 1141 177" position="1106 177" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="235" /> </Inputs> <Outputs> <Output id="236" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="590" points="394 1766, 330 1767" position="362 1766" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="154" /> </Inputs> <Outputs> <Output id="153" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="601" reactomeId="163625" points="226 671, 226 647, 226 624" position="226 647" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="305" points="175 692" /> <Input id="1906" points="226 693" /> </Inputs> <Outputs> <Output id="306" /> </Outputs> <Catalysts> <Catalyst id="1906" points="251 705, 264 705, 264 647" /> </Catalysts> <Properties> <displayName>Glucagon binds to Glucagon receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="602" reactomeId="825631" points="344 531, 344 495, 345 459" position="344 495" lineWidth="1.0"> <Inputs> <Input id="309" points="298 542" /> <Input id="312" points="366 553" /> </Inputs> <Outputs> <Output id="221" points="238 320" /> <Output id="310" points="287 469" /> <Output id="314" points="370 438" /> </Outputs> <Catalysts> <Catalyst id="306" points="290 611, 439 618, 439 494" /> </Catalysts> <Properties> <displayName>Glucagon:GCGR mediates GTP-GDP exchange</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="604" reactomeId="163617" points="140 194, 164 134, 490 132, 507 155" position="490 132" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="364" points="174 188" /> <Input id="221" points="211 291, 142 250" /> </Inputs> <Outputs> <Output id="333" /> </Outputs> <Catalysts> <Catalyst id="221" points="180 291, 114 278, 116 92, 488 92" /> </Catalysts> <Properties> <displayName>G alpha (s) activates adenylate cyclase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="605" reactomeId="164377" points="436 330, 490 357, 538 356" position="490 357" lineWidth="1.0"> <Inputs> <Input id="227" /> </Inputs> <Outputs> <Output id="229" points="614 356" /> <Output id="228" points="615 307" /> </Outputs> <Catalysts> <Catalyst id="333" points="517 198" /> </Catalysts> <Properties> <displayName>Activated Adenylate cyclase catalyses cAMP synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="607" reactomeId="111925" points="987 512, 1016 513, 1044 512" position="1016 513" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1510" /> </Inputs> <Outputs> <Output id="40" stoichiometry="2" points="1099 551" /> <Output id="340" points="1085 484" /> </Outputs> <Catalysts> <Catalyst id="1510" points="987 527, 1016 539" /> </Catalysts> <Properties> <displayName>cAMP induces dissociation of inactive PKA tetramers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="609" reactomeId="163672" points="1625 623, 1568 624, 1542 623" position="1568 624" lineWidth="1.0"> <Inputs> <Input id="21" points="1735 623" /> <Input id="610" points="1639 642" /> </Inputs> <Outputs> <Output id="1997" points="1476 623" /> <Output id="23" points="1488 591" /> <Output id="611" points="1485 658" /> </Outputs> <Catalysts> <Catalyst id="25" points="1568 666" /> </Catalysts> <Properties> <displayName>Phosphorylation of ChREBP at Thr(653) by PKA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="612" reactomeId="164423" points="1417 576, 1290 576, 1229 605" position="1290 576" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="31" /> </Outputs> <Properties> <displayName>PhosphoChREBP (Thr 653) is exported to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="613" reactomeId="163676" points="1198 694, 1199 747, 1197 865" position="1199 747" lineWidth="1.0"> <Inputs> <Input id="614" points="1227 684" /> <Input id="31" points="1206 634" /> </Inputs> <Outputs> <Output id="2002" points="1134 857" /> <Output id="38" points="1019 914" /> <Output id="1722" points="1223 883" /> </Outputs> <Catalysts> <Catalyst id="40" points="1115 586, 1135 748" /> </Catalysts> <Properties> <displayName>Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="617" reactomeId="163670" points="1263 622, 1292 624, 1428 591" position="1292 624" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="31" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Properties> <displayName>Nuclear transport of pChREBP (Thr 666) protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="618" reactomeId="163773" points="1083 727, 1085 750, 1087 783" position="1085 750" lineWidth="1.0"> <Inputs> <Input id="48" points="1056 721" /> <Input id="1616" stoichiometry="2" points="1083 696" /> </Inputs> <Outputs> <Output id="50" points="1046 808" /> <Output id="2002" stoichiometry="2" points="1107 837" /> <Output id="615" stoichiometry="2" points="1132 794" /> </Outputs> <Catalysts> <Catalyst id="40" points="1114 586, 1119 750" /> </Catalysts> <Properties> <displayName>PKA tetramer:cAMP phosphorylates PF2K-Pase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="622" reactomeId="163764" points="563 1057, 602 1057, 635 1057" position="602 1057" lineWidth="1.0"> <Inputs> <Input id="399" points="524 1038" /> <Input id="400" points="514 1074" /> </Inputs> <Outputs> <Output id="401" points="656 1071" /> <Output id="402" points="658 1041" /> </Outputs> <Catalysts> <Catalyst id="692" points="602 1114" /> </Catalysts> <Properties> <displayName>D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="623" reactomeId="163751" points="520 977, 520 941, 521 901" position="520 941" lineWidth="1.0"> <Inputs> <Input id="399" points="501 1007" /> <Input id="402" points="658 1019" /> </Inputs> <Outputs> <Output id="10" points="703 828" /> <Output id="400" points="474 1063, 431 1023" /> </Outputs> <Catalysts> <Catalyst id="411" points="558 940" /> </Catalysts> <Properties> <displayName>D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="625" reactomeId="163741" points="724 974, 724 944, 725 901" position="724 944" lineWidth="1.0"> <Inputs> <Input id="401" points="699 1067, 750 1024" /> <Input id="402" points="696 1009" /> </Inputs> <Outputs> <Output id="413" points="692 889" /> <Output id="10" points="728 838" /> </Outputs> <Catalysts> <Catalyst id="411" points="635 941" /> </Catalysts> <Properties> <displayName>D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="627" reactomeId="163664" points="1984 543, 1984 542, 1947 542" position="1984 542" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="61" points="1993 525" /> <Input id="60" points="1994 544" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> <Properties> <displayName>AMP binds to gamma subunit of AMP kinase heterotrimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="629" reactomeId="164151" points="1882 591, 1882 618, 1884 652" position="1882 618" lineWidth="1.0"> <Inputs> <Input id="62" points="1882 565" /> <Input id="69" points="1861 597" /> </Inputs> <Outputs> <Output id="64" points="1884 690" /> <Output id="2007" points="1854 661" /> <Output id="2008" points="1922 661" /> </Outputs> <Catalysts> <Catalyst id="65" points="1925 617" /> </Catalysts> <Properties> <displayName>LKB1 phosphorylates the alpha subunit of AMPK heterotrimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="633" reactomeId="163691" points="1762 674, 1762 709, 1762 739" position="1762 709" lineWidth="1.0"> <Inputs> <Input id="21" points="1762 639" /> <Input id="69" points="1821 621" /> </Inputs> <Outputs> <Output id="2011" points="1731 768" /> <Output id="86" points="1825 778" /> <Output id="2013" points="1764 775" /> </Outputs> <Catalysts> <Catalyst id="64" points="1830 710" /> </Catalysts> <Inhibitors> <Inhibitor id="2018" points="1730 709" /> </Inhibitors> <Properties> <displayName>Phosphorylation of ChREBP at Serine 556 by AMPK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="638" reactomeId="163689" points="966 907, 964 737, 965 675" position="964 737" lineWidth="1.0"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="31" points="1154 630" /> <Output id="94" points="925 671" /> </Outputs> <Catalysts> <Catalyst id="6" points="879 729" /> </Catalysts> <Activators> <Activator id="10" points="756 810" /> </Activators> <Properties> <displayName>PP2A complex dephosphorylates pChREBP (MLXIPL)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="640" reactomeId="164056" points="2012 779, 2128 771, 2128 479, 1762 479" position="2128 771" lineWidth="1.0"> <Inputs> <Input id="86" points="1897 788" /> <Input id="2093" points="1997 760" /> </Inputs> <Outputs> <Output id="106" points="1709 502" /> <Output id="21" points="1762 610" /> </Outputs> <Catalysts> <Catalyst id="104" points="2000 443, 2163 443, 2163 771" /> </Catalysts> <Properties> <displayName>Dephosphorylation of pChREBP (Ser 556) by PP2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="642" reactomeId="163688" points="1574 574, 1598 574, 1657 574" position="1598 574" lineWidth="1.0"> <Inputs> <Input id="23" points="1526 575" /> <Input id="2090" points="1540 541" /> </Inputs> <Outputs> <Output id="106" points="1683 527" /> <Output id="21" points="1737 610" /> </Outputs> <Catalysts> <Catalyst id="104" points="1892 442, 1597 442" /> </Catalysts> <Activators> <Activator id="2091" points="1628 522" /> </Activators> <Properties> <displayName>Dephosphorylation of pChREBP (Thr 666) by PP2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="644" reactomeId="163750" points="935 798, 937 772, 935 710" position="937 772" lineWidth="1.0"> <Inputs> <Input id="50" points="983 808" /> <Input id="645" stoichiometry="2" points="905 817" /> </Inputs> <Outputs> <Output id="94" stoichiometry="2" points="918 690" /> <Output id="48" points="991 714" /> </Outputs> <Catalysts> <Catalyst id="6" points="869 747" /> </Catalysts> <Activators> <Activator id="10" points="756 813" /> </Activators> <Properties> <displayName>PP2A complex dephosphorylates pPFKFB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="647" reactomeId="163666" points="1632 756, 1632 779, 1633 812" position="1632 779" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="116" points="1593 747" /> <Input id="21" points="1747 639, 1632 726" /> </Inputs> <Outputs> <Output id="117" /> </Outputs> <Properties> <displayName>Formation of ChREBP:MLX heterodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="649" reactomeId="163669" points="1382 851, 1372 1000, 1372 1173" position="1372 1000" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1911" /> </Inputs> <Outputs> <Output id="127" /> </Outputs> <Activators> <Activator id="1915" points="1411 982" /> </Activators> <Properties> <displayName>Transcriptional activation of PKLR gene by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="673" reactomeId="163770" points="1555 884, 1553 1047, 1553 1180" position="1553 1047" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1860" /> </Inputs> <Outputs> <Output id="1742" /> </Outputs> <Activators> <Activator id="1925" points="1593 1019" /> </Activators> <Properties> <displayName>Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="674" reactomeId="163733" points="1711 898, 1702 1054, 1702 1186" position="1702 1054" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1932" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Activators> <Activator id="1936" points="1735 1024" /> </Activators> <Properties> <displayName>Transcriptional activation of FASN monomer gene by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="675" reactomeId="163743" points="1846 902, 1836 1054, 1842 1180" position="1836 1054" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1946" /> </Inputs> <Outputs> <Output id="1945" /> </Outputs> <Activators> <Activator id="1957" points="1879 1018" /> </Activators> <Properties> <displayName>Transcriptional activation of ACACA by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="676" reactomeId="163748" points="2152 897, 2139 1049, 2144 1178, 2312 1214" position="2139 1049" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1964" /> </Inputs> <Outputs> <Output id="135" /> </Outputs> <Activators> <Activator id="1978" points="2173 1022" /> </Activators> <Properties> <displayName>Transcriptional activation of AGPAT1 by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1014" reactomeId="5683196" points="2611 232, 2625 178, 2609 124" position="2625 178" lineWidth="1.0"> <Inputs> <Input id="1015" /> </Inputs> <Outputs> <Output id="1016" /> </Outputs> <Catalysts> <Catalyst id="268" points="2674 178" /> </Catalysts> <Inhibitors> <Inhibitor id="269" points="3147 183, 3142 8, 2672 8" /> </Inhibitors> <Properties> <displayName>KCNJ11 tetramer:ABCC8 tetramer transports K+ from cytosol to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1019" reactomeId="5683209" points="2604 232, 2592 182, 2602 124" position="2592 182" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="1015" /> </Inputs> <Outputs> <Output id="1016" /> </Outputs> <Catalysts> <Catalyst id="1037" points="2559 180" /> </Catalysts> <Properties> <displayName>Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1729" reactomeId="434381" points="3197 1201, 3129 1201, 3062 1201" position="3129 1201" lineWidth="1.0"> <Inputs> <Input id="2030" /> </Inputs> <Outputs> <Output id="2031" /> </Outputs> <Catalysts> <Catalyst id="1733" points="3131 1172" /> </Catalysts> <Properties> <displayName>CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1734" reactomeId="434382" points="2862 1441, 2826 1441, 2763 1441" position="2826 1441" lineWidth="1.0"> <Inputs> <Input id="2037" points="2923 1405" /> <Input id="1736" points="2920 1439" /> <Input id="2031" points="3018 1221" /> </Inputs> <Outputs> <Output id="2046" points="2708 1440" /> <Output id="1741" points="2718 1404" /> <Output id="2052" points="2763 1396" /> </Outputs> <Catalysts> <Catalyst id="1739" points="2827 1476" /> </Catalysts> <Properties> <displayName>ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1861" reactomeId="9650858" points="2761 109, 2800 109, 2871 161" position="2800 109" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1862" points="2741 70" /> <Input id="268" points="2744 152" /> </Inputs> <Outputs> <Output id="1863" /> </Outputs> <Properties> <displayName>Meglitinides bind ABCC8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1864" reactomeId="9652580" points="2956 103, 2955 104, 3011 162" position="2955 104" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1865" points="2956 70" /> <Input id="268" points="2799 159" /> </Inputs> <Outputs> <Output id="1866" /> </Outputs> <Properties> <displayName>SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1894" reactomeId="9728664" points="161 1042, 161 1076, 189 1072" position="161 1042" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="209" points="179 1036" /> <Input id="1895" points="140 1038" /> </Inputs> <Outputs> <Output id="1896" /> </Outputs> <Properties> <displayName>GLP1R binds GLP1R agonists</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1897" reactomeId="9732527" points="3189 1288, 3188 1287, 3146 1252" position="3188 1287" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1898" points="3209 1280" /> <Input id="344" points="3157 1288" /> </Inputs> <Outputs> <Output id="1899" /> </Outputs> <Properties> <displayName>FFAR1 binds rosiglitazone</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1914" reactomeId="9856539" points="1407 872, 1431 906, 1441 938" position="1431 906" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="117" stoichiometry="2" points="1593 833" /> <Input id="1911" points="1382 851" /> </Inputs> <Outputs> <Output id="1915" /> </Outputs> <Catalysts> <Catalyst id="117" points="1604 841" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds PKLR gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1924" reactomeId="9856549" points="1584 903, 1612 944, 1615 977" position="1612 944" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1860" points="1555 884" /> <Input id="117" stoichiometry="2" points="1626 841" /> </Inputs> <Outputs> <Output id="1925" /> </Outputs> <Catalysts> <Catalyst id="117" points="1631 841" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds ACLY gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1935" reactomeId="9856546" points="1718 881, 1744 907, 1752 978" position="1744 907" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="117" stoichiometry="2" points="1651 841" /> <Input id="1932" points="1711 898" /> </Inputs> <Outputs> <Output id="1936" /> </Outputs> <Catalysts> <Catalyst id="117" points="1657 841, 1746 880" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds FASN gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1955" reactomeId="9856548" points="2014 926, 2035 946, 2042 975" position="2035 946" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="117" stoichiometry="2" points="1676 832, 2012 889" /> <Input id="1952" points="1991 900" /> </Inputs> <Outputs> <Output id="1954" /> </Outputs> <Catalysts> <Catalyst id="117" points="1676 830, 2033 877" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds ACACB gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1956" reactomeId="9856550" points="1865 925, 1889 946, 1896 974" position="1889 946" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1946" points="1846 902" /> <Input id="117" stoichiometry="2" points="1676 837, 1866 894" /> </Inputs> <Outputs> <Output id="1957" /> </Outputs> <Catalysts> <Catalyst id="117" points="1676 834, 1887 884" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds ACACA gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1968" reactomeId="9856605" points="1991 900, 1986 1052, 1986 1178" position="1986 1052" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1952" /> </Inputs> <Outputs> <Output id="1953" /> </Outputs> <Activators> <Activator id="1954" points="2025 1019" /> </Activators> <Properties> <displayName>Transcriptional activation of ACACB by ChREBP:MLX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1977" reactomeId="9856604" points="2173 923, 2193 942, 2194 979" position="2193 942" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1964" points="2152 897" /> <Input id="117" stoichiometry="2" points="1676 829, 2170 872" /> </Inputs> <Outputs> <Output id="1978" /> </Outputs> <Catalysts> <Catalyst id="117" points="1676 827, 2190 850" /> </Catalysts> <Properties> <displayName>MLXIPL:MLX binds AGPAT1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2084" points="1970 159, 1989 135, 2040 156" position="1989 135" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="248" /> </Inputs> <Outputs> <Output id="2083" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2085" points="1755 169, 1990 112, 2053 156" position="1990 112" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="244" /> </Inputs> <Outputs> <Output id="2083" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2092" reactomeId="8848663" points="1363 1798, 1413 1798, 1445 1787" position="1413 1798" lineWidth="1.0"> <Inputs> <Input id="1507" points="1348 1781" /> <Input id="1508" points="1344 1827" /> </Inputs> <Outputs> <Output id="1192" /> </Outputs> <Catalysts> <Catalyst id="1508" points="1388 1837, 1410 1836" /> </Catalysts> <Properties> <displayName>ADIPOQ trimer binds ADIPOR dimers</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Integration of energy metabolism and Defective ABCC8 can cause hypo- and hyper-glycemias (660251)
