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Details on Person UniProt:Q8WXI4 ACOT11

Class:Id	ReferenceGeneProduct:65989
_chainChangeLog	chain:1-607 added on Fri February 6 2015;chain:1-607 for 65989 removed on Fri August 9 2019;transit peptide:1-13 for 65989 added on Fri August 9 2019;chain:14-607 for 65989 added on Fri August 9 2019
_displayName	UniProt:Q8WXI4 ACOT11
_timestamp	2025-02-21 19:14:59
chain	transit peptide:1-13 chain:14-607
checksum	12F2BCAB8AAC18EC
comment	FUNCTION Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway.CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)CATALYTIC ACTIVITY butanoyl-CoA + H2O = butanoate + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 5 min(-1) for the hydrolysis of hexadecanoyl-CoA (PubMed:22897136). kcat is 3.5 min(-1) for the hydrolysis of tetradecanoyl-CoA (PubMed:22897136). kcat is 2.3 min(-1) for the hydrolysis of dodecanoyl-CoA (PubMed:22897136). kcat is 0.2 min(-1) for the hydrolysis of butanoyl-CoA (PubMed:22897136).PATHWAY Lipid metabolism; fatty acid metabolism.INTERACTION Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.INDUCTION By cold exposure and repressed by heat exposure.
description	recommendedName: fullName evidence="13"Acyl-coenzyme A thioesterase 11 shortName evidence="13"Acyl-CoA thioesterase 11 ecNumber evidence="6"3.1.2.- alternativeName: Acyl-CoA thioester hydrolase 11 alternativeName: Adipose-associated thioesterase alternativeName: Brown fat-inducible thioesterase shortName: BFIT alternativeName: fullName evidence="13"Palmitoyl-coenzyme A thioesterase ecNumber evidence="6"3.1.2.2
geneName	ACOT11 BFIT KIAA0707 THEA
identifier	Q8WXI4
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cytoplasm Fatty acid metabolism Hydrolase Lipid metabolism Mitochondrion Phosphoprotein Proteomics identification Reference proteome Repeat Serine esterase Transit peptide
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	ACOT11
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000446] ENSEMBL:ENSG00000162390 ACOT11 [Homo sapiens]
secondaryIdentifier	ACO11_HUMAN B1AQ22 D3DQ50 O75187 Q52LP1 Q53ER9 Q96DI1 Q9H883
sequenceLength	607
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:154893] UniProt:Q8WXI4-2 ACOT11 [Homo sapiens] [ReferenceIsoform:412171] UniProt:Q8WXI4-1 ACOT11 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5690049] ACOT11 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q8WXI4 ACOT11 (65989)