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Details on Person UniProt:P24557 TBXAS1
| Class:Id | ReferenceGeneProduct:65977 |
|---|---|
| _chainChangeLog | chain:1-533 added on Sat February 7 2015 |
| _displayName | UniProt:P24557 TBXAS1 |
| _timestamp | 2025-05-21 21:52:49 |
| chain | chain:1-533 |
| checksum | E95E7B7EA77E6DDC |
| comment | FUNCTION Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:22735388, PubMed:9873013). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323).CATALYTIC ACTIVITY prostaglandin H2 = thromboxane A2CATALYTIC ACTIVITY prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehydeCATALYTIC ACTIVITY a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2OCOFACTOR Lipid metabolism; fatty acid metabolism.SUBUNIT Monomer.INTERACTION Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Thromboxane synthetase deficiency has been detected in some patients with a bleeding disorder due to platelet dysfunction.SIMILARITY Belongs to the cytochrome P450 family.CAUTION It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammals.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION CYP5A1 alleles |
| description | recommendedName: Thromboxane-A synthase shortName: TXA synthase shortName evidence="24"TXS ecNumber evidence="5 6 13 14 18 19"5.3.99.5 alternativeName: Cytochrome P450 5A1 alternativeName: fullName evidence="25"Hydroperoxy icosatetraenoate dehydratase ecNumber evidence="11"4.2.1.152 |
| geneName | TBXAS1 CYP5 CYP5A1 TXAS |
| identifier | P24557 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Direct protein sequencing Disease variant Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Heme Iron Isomerase Lipid biosynthesis Lipid metabolism Lyase Membrane Metal-binding Monooxygenase Oxidoreductase Prostaglandin biosynthesis Prostaglandin metabolism Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | TBXAS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996919] ENSEMBL:ENSG00000059377 TBXAS1 [Homo sapiens] |
| secondaryIdentifier | THAS_HUMAN B4DJG6 E7EMU9 E7EP08 E7ESB5 O14987 Q16843 Q16844 Q8IUN1 Q96CN2 Q9GZW4 Q9HD77 Q9HD78 Q9HD79 Q9HD80 Q9HD81 Q9HD82 Q9HD83 Q9HD84 |
| sequenceLength | 533 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974938] UniProt:P24557-1 TBXAS1 [Homo sapiens] [ReferenceIsoform:8974939] UniProt:P24557-2 TBXAS1 [Homo sapiens] [ReferenceIsoform:8974940] UniProt:P24557-3 TBXAS1 [Homo sapiens] [ReferenceIsoform:8974941] UniProt:P24557-4 TBXAS1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65976] TBXAS1 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5603341] TBXAS1 L83P [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5603342] TBXAS1 L488P [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5603356] TBXAS1 R413E [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5603378] TBXAS1 G482W [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5603334] L-leucine 488 replaced with L-proline [ReplacedResidue:5603345] glycine 482 replaced with L-tryptophan [ReplacedResidue:5603363] L-leucine 83 replaced with L-proline [ReplacedResidue:5603376] L-arginine 413 replaced with L-glutamic acid |
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No pathways have been reviewed or authored by UniProt:P24557 TBXAS1 (65977)
