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Details on Person UniProt:O00292 LEFTY2
| Class:Id | ReferenceGeneProduct:65945 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Sat February 7 2015;propeptide:22-76 added on Sat February 7 2015;chain:77-366 added on Sat February 7 2015 |
| _displayName | UniProt:O00292 LEFTY2 |
| _timestamp | 2024-11-03 20:05:59 |
| chain | signal peptide:1-21 propeptide:22-76 chain:77-366 |
| checksum | 63A416CAE30F7A39 |
| comment | FUNCTION Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.SUBCELLULAR LOCATION Mesenchymal cells of the endometrial stroma.DEVELOPMENTAL STAGE Transiently expressed before and during menstrual bleeding.PTM The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TGF-beta family.SEQUENCE CAUTION Authors have revised their sequence, but have not submitted the revised DNA sequence. |
| description | recommendedName: Left-right determination factor 2 alternativeName: Endometrial bleeding-associated factor alternativeName: Left-right determination factor A alternativeName: Protein lefty-2 alternativeName: Protein lefty-A alternativeName: Transforming growth factor beta-4 shortName: TGF-beta-4 |
| geneName | LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024 |
| identifier | O00292 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytokine Developmental protein Disease variant Disulfide bond Glycoprotein Growth factor Heterotaxy Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LEFTY2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888897] ENSEMBL:ENSG00000143768 LEFTY2 [Homo sapiens] |
| secondaryIdentifier | LFTY2_HUMAN B3KNH4 B4E332 E9PDM4 O75611 Q5TE89 Q8NBQ9 |
| sequenceLength | 366 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975630] UniProt:O00292-1 LEFTY2 [Homo sapiens] [ReferenceIsoform:8975631] UniProt:O00292-2 LEFTY2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65944] LEFTY2 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114708] LEFTY2(22-366) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O00292 LEFTY2 (65945)
