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Details on Person UniProt:P10600 TGFB3

Class:Id	ReferenceGeneProduct:65943
_chainChangeLog	signal peptide:1-23 added on Sat February 7 2015;chain:24-300 added on Sat February 7 2015;chain:301-412 added on Sat February 7 2015
_displayName	UniProt:P10600 TGFB3
_timestamp	2024-11-03 20:17:04
chain	signal peptide:1-23 chain:24-300 chain:301-412
checksum	3CAD3548D3AEA178
comment	FUNCTION Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.FUNCTION Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).FUNCTION Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).SUBUNIT Interacts with ASPN (PubMed:8819159). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (PubMed:8819159). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).INTERACTION Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.PTM Methylated at Gln-293 by N6AMT1.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TGF-beta family.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION TGF beta-3 entry
description	recommendedName: Transforming growth factor beta-3 proprotein component recommendedName: Latency-associated peptide shortName: LAP /component component recommendedName: Transforming growth factor beta-3 shortName: TGF-beta-3 /component
geneName	TGFB3
identifier	P10600
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cardiomyopathy Cleavage on pair of basic residues Disease variant Disulfide bond Extracellular matrix Glycoprotein Growth factor Methylation Mitogen Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	TGFB3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8992783] ENSEMBL:ENSG00000119699 TGFB3 [Homo sapiens]
secondaryIdentifier	TGFB3_HUMAN Q8WV88
sequenceLength	412
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8973538] UniProt:P10600-1 TGFB3 [Homo sapiens] [ReferenceIsoform:8973539] UniProt:P10600-2 TGFB3 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:65942] TGFB3 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114707] TGFB3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2395290] TGFB3(24-300) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9729940] TGFB3(24-412) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:9729954] TGFB3(24-300) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:9729957] TGFB3 [Golgi lumen] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P10600 TGFB3 (65943)