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Details on Person UniProt:Q13889 GTF2H3
| Class:Id | ReferenceGeneProduct:65917 |
|---|---|
| _chainChangeLog | chain:1-308 added on Sat February 7 2015 |
| _displayName | UniProt:Q13889 GTF2H3 |
| _timestamp | 2024-11-03 19:58:55 |
| chain | chain:1-308 |
| checksum | E739E2176CD6BAA5 |
| comment | FUNCTION Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.SUBUNIT Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682). Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:9852112). Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7 (By similarity).INTERACTION Belongs to the TFB4 family. |
| description | recommendedName: General transcription factor IIH subunit 3 alternativeName: Basic transcription factor 2 34 kDa subunit shortName evidence="6"BTF2 p34 alternativeName: General transcription factor IIH polypeptide 3 alternativeName: fullName evidence="6"TFIIH basal transcription factor complex p34 subunit |
| geneName | GTF2H3 |
| identifier | Q13889 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing DNA damage DNA repair Metal-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GTF2H3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002081] ENSEMBL:ENSG00000111358 GTF2H3 [Homo sapiens] |
| secondaryIdentifier | TF2H3_HUMAN B2R819 B4DNZ6 Q7L0G0 Q96AT7 |
| sequenceLength | 308 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964995] UniProt:Q13889-1 GTF2H3 [Homo sapiens] [ReferenceIsoform:8964996] UniProt:Q13889-2 GTF2H3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65916] GTF2H3 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13889 GTF2H3 (65917)
