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Details on Person UniProt:P32780 GTF2H1
| Class:Id | ReferenceGeneProduct:65913 |
|---|---|
| _chainChangeLog | chain:1-548 added on Fri February 6 2015 |
| _displayName | UniProt:P32780 GTF2H1 |
| _timestamp | 2025-02-21 19:23:37 |
| chain | chain:1-548 |
| checksum | 8F0FCEBBB1FC9C1D |
| comment | FUNCTION Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.SUBUNIT Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60.SUBUNIT (Microbial infection) Interacts with Rift valley fever virus NSs (via OmegaXaV motif); the interaction leads to TFIIH complex proteasomal degradation.INTERACTION (Microbial infection) Upon Rift valley fever virus infection, interacts with NSs leading to ubiquitination by the NSs-FBXO3 E3 ligase and proteasome-dependent degradation.SIMILARITY Belongs to the TFB1 family. |
| description | recommendedName: General transcription factor IIH subunit 1 alternativeName: Basic transcription factor 2 62 kDa subunit shortName: BTF2 p62 alternativeName: General transcription factor IIH polypeptide 1 alternativeName: TFIIH basal transcription factor complex p62 subunit |
| geneName | GTF2H1 BTF2 |
| identifier | P32780 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing DNA damage DNA repair Host-virus interaction Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GTF2H1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990450] ENSEMBL:ENSG00000110768 GTF2H1 [Homo sapiens] |
| secondaryIdentifier | TF2H1_HUMAN B3KXE0 D3DQY2 Q6I9Y7 Q9H5K5 Q9NQD9 |
| sequenceLength | 548 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968081] UniProt:P32780-1 GTF2H1 [Homo sapiens] [ReferenceIsoform:8968082] UniProt:P32780-2 GTF2H1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65912] GTF2H1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P32780 GTF2H1 (65913)
