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Details on Person UniProt:Q92664 GTF3A
| Class:Id | ReferenceGeneProduct:65893 |
|---|---|
| _chainChangeLog | chain:1-365 added on Fri February 6 2015 |
| _displayName | UniProt:Q92664 GTF3A |
| _timestamp | 2024-11-03 19:54:18 |
| chain | chain:1-365 |
| checksum | 261EBDCC550130B9 |
| comment | FUNCTION Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).SUBCELLULAR LOCATION Ubiquitous.CAUTION It is uncertain whether Met-1 is the initiator. Based on the lack of an in-frame AUG codon, mammalian TFIIIA may be translated from this non-AUG initiation site, which has a good Kozak context and which is well conserved among mammals.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Transcription factor IIIA shortName: TFIIIA |
| geneName | GTF3A |
| identifier | Q92664 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing DNA-binding Metal-binding Nucleus Proteomics identification Reference proteome Repeat Ribosome biogenesis RNA-binding Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GTF3A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002082] ENSEMBL:ENSG00000122034 GTF3A [Homo sapiens] |
| secondaryIdentifier | TF3A_HUMAN B7ZBK5 Q12963 Q13097 |
| sequenceLength | 365 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:251002] UniProt:Q92664-2 GTF3A [Homo sapiens] [ReferenceIsoform:412474] UniProt:Q92664-1 GTF3A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65892] GTF3A [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92664 GTF3A (65893)
