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Details on Person UniProt:Q15185 PTGES3

Class:Id	ReferenceGeneProduct:65839
_chainChangeLog	chain:1-160 added on Fri February 6 2015
_displayName	UniProt:Q15185 PTGES3
_timestamp	2024-11-03 20:03:33
chain	chain:1-160
checksum	23538BB9D7AFD73F
comment	FUNCTION Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).CATALYTIC ACTIVITY prostaglandin H2 = prostaglandin E2BIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; prostaglandin biosynthesis.SUBUNIT Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Binds to the progesterone receptor (PubMed:8114727). Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex (PubMed:11274138). Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation (PubMed:24711448). Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2 (PubMed:27353360).INTERACTION The PXLE motif mediates interaction with EGLN1/PHD2.PTM Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.SIMILARITY Belongs to the p23/wos2 family.
description	recommendedName: Prostaglandin E synthase 3 ecNumber evidence="5"5.3.99.3 alternativeName: Cytosolic prostaglandin E2 synthase shortName: cPGES alternativeName: Hsp90 co-chaperone alternativeName: Progesterone receptor complex p23 alternativeName: Telomerase-binding protein p23
geneName	PTGES3 P23 TEBP
identifier	Q15185
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Direct protein sequencing Fatty acid biosynthesis Fatty acid metabolism Isomerase Isopeptide bond Lipid biosynthesis Lipid metabolism Phosphoprotein Prostaglandin biosynthesis Prostaglandin metabolism Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	PTGES3
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8954529] ENSEMBL:ENSG00000110958 PTGES3 [Homo sapiens]
secondaryIdentifier	TEBP_HUMAN A8K7D0 B4DHP2 B4DP11 B4DP21 Q8WU70
sequenceLength	160
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8971230] UniProt:Q15185-1 PTGES3 [Homo sapiens] [ReferenceIsoform:8971231] UniProt:Q15185-2 PTGES3 [Homo sapiens] [ReferenceIsoform:8971232] UniProt:Q15185-3 PTGES3 [Homo sapiens] [ReferenceIsoform:8971233] UniProt:Q15185-4 PTGES3 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:265269] PTGES3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5082403] PTGES3 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q15185 PTGES3 (65839)