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Details on Person UniProt:P17987 TCP1
| Class:Id | ReferenceGeneProduct:65773 |
|---|---|
| _chainChangeLog | chain:1-556 added on Fri February 6 2015 |
| _displayName | UniProt:P17987 TCP1 |
| _timestamp | 2025-08-15 22:04:50 |
| chain | chain:1-556 |
| checksum | 486ECA836EA258A1 |
| comment | FUNCTION Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber (PubMed:1630492, PubMed:20080638, PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8 (PubMed:36493755, PubMed:35449234, PubMed:37193829). Interacts with PACRG (PubMed:14532270). Interacts with GBA1 (PubMed:21098288). Interacts with DLEC1 (PubMed:33144677).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TCP-1 chaperonin family. |
| description | recommendedName: T-complex protein 1 subunit alpha shortName: TCP-1-alpha ecNumber evidence="19 20 21"3.6.1.- alternativeName: CCT-alpha alternativeName: fullName evidence="23"Chaperonin containing T-complex polypeptide 1 subunit 1 |
| geneName | TCP1 CCT1 CCTA |
| identifier | P17987 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Chaperone Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Epilepsy Hydrolase Intellectual disability Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TCP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8950345] ENSEMBL:ENSG00000120438 TCP1 [Homo sapiens] |
| secondaryIdentifier | TCPA_HUMAN E1P5B2 Q15556 Q5TCM3 |
| sequenceLength | 556 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:390448] TCP1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P17987 TCP1 (65773)
