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Details on Person UniProt:O15119 TBX3
| Class:Id | ReferenceGeneProduct:65731 |
|---|---|
| _chainChangeLog | chain:1-743 added on Sat February 7 2015 |
| _displayName | UniProt:O15119 TBX3 |
| _timestamp | 2024-11-03 19:54:17 |
| chain | chain:1-743 |
| checksum | D5572F9CF871E89F |
| comment | FUNCTION Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537).SUBUNIT Interacts with PML (isoform PML-4).INTERACTION Widely expressed.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Contains an interrupted T-box domain.MISCELLANEOUS Contains an interrupted T-box domain.MISCELLANEOUS May be produced by joining exon 1 to exon 7 thereby eliminating the T-box. |
| description | recommendedName: T-box transcription factor TBX3 shortName: T-box protein 3 |
| geneName | TBX3 |
| identifier | O15119 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Developmental protein Disease variant DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TBX3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989260] ENSEMBL:ENSG00000135111 TBX3 [Homo sapiens] |
| secondaryIdentifier | TBX3_HUMAN Q8TB20 Q9UKF8 |
| sequenceLength | 743 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154758] UniProt:O15119-2 TBX3 [Homo sapiens] [ReferenceIsoform:154759] UniProt:O15119-3 TBX3 [Homo sapiens] [ReferenceIsoform:154760] UniProt:O15119-4 TBX3 [Homo sapiens] [ReferenceIsoform:401304] UniProt:O15119-1 TBX3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9825678] TBX3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9825680] p-S742 TBX3 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9825681] O-phospho-L-serine at 742 |
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No pathways have been reviewed or authored by UniProt:O15119 TBX3 (65731)
