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Details on Person UniProt:Q9BZK7 TBL1XR1
| Class:Id | ReferenceGeneProduct:65719 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-514 added on Sat February 7 2015;initiator methionine:1 for 65719 removed on Fri Nov 03 2023;initiator methionine: for 65719 added on Fri Nov 03 2023;initiator methionine: for 65719 removed on Fri Aug 15 2025;initiator methionine:1 for 65719 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BZK7 TBL1XR1 |
| _timestamp | 2025-08-15 22:04:49 |
| chain | initiator methionine:1 chain:2-514 |
| checksum | 0B556D2EE4BA796D |
| comment | FUNCTION F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.SUBUNIT Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2 (PubMed:11931768). Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4 (PubMed:12628926). Interacts with MECP2; bridges interaction between MECP2 and NCOR1 (By similarity). Interacts with USP44 (PubMed:27880911).INTERACTION Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.DOMAIN The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the WD repeat EBI family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| description | recommendedName: F-box-like/WD repeat-containing protein TBL1XR1 alternativeName: Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 alternativeName: TBL1-related protein 1 alternativeName: Transducin beta-like 1X-related protein 1 |
| geneName | TBL1XR1 IRA1 TBLR1 |
| identifier | Q9BZK7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Chromatin regulator Disease variant Intellectual disability Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Ubl conjugation pathway WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TBL1XR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995169] ENSEMBL:ENSG00000177565 TBL1XR1 [Homo sapiens] |
| secondaryIdentifier | TBL1R_HUMAN D3DNQ9 Q14DC3 Q9H2I1 Q9H9A1 |
| sequenceLength | 514 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:351643] TBL1XR1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BZK7 TBL1XR1 (65719)
