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Details on Person UniProt:P37837 TALDO1
| Class:Id | ReferenceGeneProduct:65630 |
|---|---|
| _chainChangeLog | chain:1-337 added on Fri February 6 2015 |
| _displayName | UniProt:P37837 TALDO1 |
| _timestamp | 2025-08-15 21:26:54 |
| chain | chain:1-337 |
| checksum | 8CB4992AEF364E64 |
| comment | FUNCTION Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:18687684, PubMed:8955144). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).CATALYTIC ACTIVITY D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphatePATHWAY Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.SUBUNIT Homodimer (PubMed:10869557). Heterodimer with isoform 2 (By similarity). Interacts with KPNA1 and KPNA4 (By similarity).INTERACTION Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1.SUBCELLULAR LOCATION Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer.ALTERNATIVE PRODUCTS The first 10 amino acids are essential for nuclear localization.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the transaldolase family. Type 1 subfamily. |
| description | recommendedName: Transaldolase ecNumber evidence="4 6"2.2.1.2 |
| geneName | TALDO1 TAL TALDO TALDOR |
| identifier | P37837 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Cytoplasm Disease variant Nucleus Pentose shunt Phosphoprotein Proteomics identification Reference proteome Schiff base Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TALDO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8950404] ENSEMBL:ENSG00000177156 TALDO1 [Homo sapiens] |
| secondaryIdentifier | TALDO_HUMAN B2R8M2 O00751 Q8WV32 Q8WZ45 |
| sequenceLength | 337 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:9814913] UniProt:P37837-1 TALDO1 [Homo sapiens] [ReferenceIsoform:9814914] UniProt:P37837-2 TALDO1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:71325] TALDO1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5659976] TALDO1 R192C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5659977] TALDO1 S171F [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5659979] TALDO1 R192H [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8957489] TALDO1 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5659999] L-arginine 192 replaced with L-histidine [ReplacedResidue:5660000] L-arginine 192 replaced with L-cysteine [ReplacedResidue:5660007] L-serine 171 replaced with L-phenylalanine |
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No pathways have been reviewed or authored by UniProt:P37837 TALDO1 (65630)
