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Details on Person UniProt:P13984 GTF2F2
| Class:Id | ReferenceGeneProduct:65568 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-249 added on Fri February 6 2015;initiator methionine:1 for 65568 removed on Fri Nov 03 2023;initiator methionine: for 65568 added on Fri Nov 03 2023;initiator methionine: for 65568 removed on Fri Aug 15 2025;initiator methionine:1 for 65568 added on Fri Aug 15 2025 |
| _displayName | UniProt:P13984 GTF2F2 |
| _timestamp | 2025-08-15 21:11:37 |
| chain | initiator methionine:1 chain:2-249 |
| checksum | 05A1A9F8D31B749C |
| comment | FUNCTION TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.SUBUNIT Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1. Interacts with GTF2B (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.INTERACTION Belongs to the TFIIF beta subunit family.CAUTION GTF2F2 appears to have ATP-dependent DNA-helicase activity; however this is probably an artifact that happened during the protein purification. |
| description | recommendedName: General transcription factor IIF subunit 2 alternativeName: General transcription factor IIF 30 kDa subunit alternativeName: Transcription initiation factor IIF subunit beta shortName: TFIIF-beta alternativeName: Transcription initiation factor RAP30 |
| geneName | GTF2F2 RAP30 |
| identifier | P13984 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GTF2F2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991590] ENSEMBL:ENSG00000188342 GTF2F2 [Homo sapiens] |
| secondaryIdentifier | T2FB_HUMAN A6NNS5 Q5W0H3 |
| sequenceLength | 249 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65567] GTF2F2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P13984 GTF2F2 (65568)
