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Details on Person UniProt:P35269 GTF2F1
| Class:Id | ReferenceGeneProduct:65566 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-517 added on Fri February 6 2015;initiator methionine:1 for 65566 removed on Fri Nov 03 2023;initiator methionine: for 65566 added on Fri Nov 03 2023;initiator methionine: for 65566 removed on Fri Aug 15 2025;initiator methionine:1 for 65566 added on Fri Aug 15 2025 |
| _displayName | UniProt:P35269 GTF2F1 |
| _timestamp | 2025-08-15 21:11:37 |
| chain | initiator methionine:1 chain:2-517 |
| checksum | 1032B04A36BDC24F |
| comment | FUNCTION TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.SUBUNIT Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Interacts with GTF2B (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:12931194, PubMed:8662660). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.INTERACTION Up-regulated in response to enterovirus 71 (EV71) infection.PTM Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.SIMILARITY Belongs to the TFIIF alpha subunit family.CAUTION Was reported to have a protein kinase activity and to autophosphorylates on Ser-385 and Thr-389. |
| description | recommendedName: General transcription factor IIF subunit 1 alternativeName: General transcription factor IIF 74 kDa subunit alternativeName: Transcription initiation factor IIF subunit alpha shortName: TFIIF-alpha alternativeName: Transcription initiation factor RAP74 |
| geneName | GTF2F1 RAP74 |
| identifier | P35269 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GTF2F1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998626] ENSEMBL:ENSG00000125651 GTF2F1 [Homo sapiens] |
| secondaryIdentifier | T2FA_HUMAN B2RCS0 Q9BWN0 |
| sequenceLength | 517 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65565] GTF2F1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P35269 GTF2F1 (65566)
