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Details on Person UniProt:P29083 GTF2E1
| Class:Id | ReferenceGeneProduct:65562 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-439 added on Sat February 7 2015;initiator methionine:1 for 65562 removed on Fri Nov 03 2023;initiator methionine: for 65562 added on Fri Nov 03 2023;initiator methionine: for 65562 removed on Fri Aug 15 2025;initiator methionine:1 for 65562 added on Fri Aug 15 2025 |
| _displayName | UniProt:P29083 GTF2E1 |
| _timestamp | 2025-08-15 22:12:21 |
| chain | initiator methionine:1 chain:2-439 |
| checksum | 9234FFE3F150340B |
| comment | FUNCTION Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.SUBUNIT Tetramer of two alpha and two beta chains (PubMed:1956398). Interacts with TAF6/TAFII80 (PubMed:7667268). Interacts with ATF7IP (PubMed:19106100). Interacts with SND1 (PubMed:7651391). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.SUBUNIT (Microbial infection) Interacts with varicella-zoster virus IE63 protein.INTERACTION Belongs to the TFIIE alpha subunit family. |
| description | recommendedName: General transcription factor IIE subunit 1 alternativeName: General transcription factor IIE 56 kDa subunit alternativeName: Transcription initiation factor IIE subunit alpha shortName: TFIIE-alpha |
| geneName | GTF2E1 TF2E1 |
| identifier | P29083 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Host-virus interaction Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GTF2E1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996902] ENSEMBL:ENSG00000153767 GTF2E1 [Homo sapiens] |
| secondaryIdentifier | T2EA_HUMAN Q16103 |
| sequenceLength | 439 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65561] GTF2E1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P29083 GTF2E1 (65562)
