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Details on Person UniProt:Q16514 TAF12
| Class:Id | ReferenceGeneProduct:65556 |
|---|---|
| _chainChangeLog | chain:1-161 added on Fri February 6 2015 |
| _displayName | UniProt:Q16514 TAF12 |
| _timestamp | 2024-11-03 20:03:30 |
| chain | chain:1-161 |
| checksum | 054B017CD7BF99CE |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:10594036, PubMed:11564863, PubMed:9885574). Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574). Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:10594036, PubMed:11564863). Interacts with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 (PubMed:15735663).SUBUNIT Interacts with TBP; the interaction is direct (PubMed:7729427). Interacts with TAF10; the interaction is direct (PubMed:7729427). Interacts with ATF7, promoting transactivation by ATF7 (PubMed:15735663).SUBUNIT Does not promote the transactivation of ATF7.INTERACTION Ubiquitous.SIMILARITY Belongs to the TAF12 family. |
| description | recommendedName: fullName evidence="14"Transcription initiation factor TFIID subunit 12 alternativeName: fullName evidence="14"Transcription initiation factor TFIID 20/15 kDa subunits shortName evidence="14"TAFII-20/TAFII-15 shortName evidence="15"TAFII20/TAFII15 |
| geneName | TAF12 TAF15 TAF2J TAFII20 |
| identifier | Q16514 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996906] ENSEMBL:ENSG00000120656 TAF12 [Homo sapiens] |
| secondaryIdentifier | TAF12_HUMAN D3DPM5 Q15775 Q5T077 |
| sequenceLength | 161 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:250376] UniProt:Q16514-2 TAF12 [Homo sapiens] [ReferenceIsoform:405908] UniProt:Q16514-1 TAF12 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65555] TAF12 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16514 TAF12 (65556)
