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Details on Person UniProt:Q12962 TAF10
| Class:Id | ReferenceGeneProduct:65552 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-218 added on Fri February 6 2015;initiator methionine:1 for 65552 removed on Fri Nov 03 2023;initiator methionine: for 65552 added on Fri Nov 03 2023;initiator methionine: for 65552 removed on Fri Aug 15 2025;initiator methionine:1 for 65552 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q12962 TAF10 |
| _timestamp | 2025-08-15 21:49:33 |
| chain | initiator methionine:1 chain:2-218 |
| checksum | 032ED5CA97EBE411 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:12601814, PubMed:18206972, PubMed:9885574). May regulate cyclin E expression (By similarity).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:12601814, PubMed:18206972, PubMed:9885574). The PCAF complex consists at least of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574). The TFTC-HAT complex consists at least of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP (PubMed:10373431, PubMed:12601814). The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:11564863, PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (PubMed:18206972). Interacts with TAF3 (PubMed:11438666). Interacts with LOXL2 (PubMed:25959397). Interacts with TAF12 isoform TAFII20; the interaction is direct (PubMed:7729427).INTERACTION The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.PTM Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.PTM Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.SIMILARITY Belongs to the TAF10 family. |
| description | recommendedName: Transcription initiation factor TFIID subunit 10 alternativeName: STAF28 alternativeName: Transcription initiation factor TFIID 30 kDa subunit shortName: TAF(II)30 shortName: TAFII-30 shortName: TAFII30 |
| geneName | TAF10 TAF2A TAF2H TAFII30 |
| identifier | Q12962 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TAF10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003270] ENSEMBL:ENSG00000166337 TAF10 [Homo sapiens] |
| secondaryIdentifier | TAF10_HUMAN O00703 Q13175 Q6FH13 |
| sequenceLength | 218 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65551] TAF10 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q12962 TAF10 (65552)
