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Details on Person UniProt:P49848 TAF6
| Class:Id | ReferenceGeneProduct:65546 |
|---|---|
| _chainChangeLog | chain:1-677 added on Sat February 7 2015 |
| _displayName | UniProt:P49848 TAF6 |
| _timestamp | 2025-02-21 19:54:42 |
| chain | chain:1-677 |
| checksum | 06C6BFA563580823 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473).FUNCTION Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700).SUBUNIT Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:8262073). Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 and TAF12/TAFII20 (PubMed:7667268). The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer (PubMed:15601843). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1 (PubMed:7667268). Component of the TBP-free TAFII-histone acetylase complex (TFTC-HAT) (PubMed:12601814).SUBUNIT Interacts with TP53/p53.SUBUNIT Not part of the TBP-free TAFII-histone acetylase complex (TFTC-HAT) (PubMed:11583621). Part of a TFIID-like complex which lacks TAF9 (PubMed:11583621). Interacts with TP53/p53 (PubMed:20096117).INTERACTION Induced in cells undergoing apoptosis.PTM In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TAF6 family. |
| description | recommendedName: Transcription initiation factor TFIID subunit 6 alternativeName: RNA polymerase II TBP-associated factor subunit E alternativeName: Transcription initiation factor TFIID 70 kDa subunit shortName: TAF(II)70 shortName: TAFII-70 shortName: TAFII70 alternativeName: Transcription initiation factor TFIID 80 kDa subunit shortName: TAF(II)80 shortName: TAFII-80 shortName: TAFII80 |
| geneName | TAF6 TAF2E TAFII70 |
| identifier | P49848 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Direct protein sequencing Disease variant Intellectual disability Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TAF6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995731] ENSEMBL:ENSG00000106290 TAF6 [Homo sapiens] |
| secondaryIdentifier | TAF6_HUMAN A4D2B2 A4D2B3 B4DT11 D6W5U2 Q6AI29 |
| sequenceLength | 677 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:436216] UniProt:P49848-1 TAF6 [Homo sapiens] [ReferenceIsoform:436217] UniProt:P49848-2 TAF6 [Homo sapiens] [ReferenceIsoform:8972197] UniProt:P49848-3 TAF6 [Homo sapiens] [ReferenceIsoform:9627882] UniProt:P49848-4 TAF6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65545] TAF6 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P49848 TAF6 (65546)
