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Details on Person UniProt:Q15542 TAF5
| Class:Id | ReferenceGeneProduct:65544 |
|---|---|
| _chainChangeLog | chain:1-800 added on Fri February 6 2015 |
| _displayName | UniProt:Q15542 TAF5 |
| _timestamp | 2024-11-03 19:39:06 |
| chain | chain:1-800 |
| checksum | 87A178BFB7071992 |
| comment | FUNCTION The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:8758937, PubMed:8942982, PubMed:9045704). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8 (PubMed:33795473). Involved in contacts between TFIID and TFIIF in the PIC (PubMed:33795473).SUBUNIT Homodimer (PubMed:17227857). Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10373431, PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF5 forms the TFIID-A module together with TAF3 and TBP, and in TFIID-B with TAF8 (PubMed:33795473). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP (PubMed:10373431, PubMed:12601814, PubMed:17227857). TBP is not part of the TFTC-HAT complex (PubMed:10373431, PubMed:12601814). Interacts strongly with the histone H4-related TAF6 and the histone H3-related TAF9, as well as a stable complex comprised of both TAF6 and TAF9 (PubMed:9045704). Apparently weaker interactions with TBP, TAF1, TAF11, and TAF12, but not TAF7, also have been observed (PubMed:8758937, PubMed:9045704).SUBUNIT (Microbial infection) Interacts with SV40 Large T antigen.INTERACTION Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.SIMILARITY Belongs to the WD repeat TAF5 family. |
| description | recommendedName: Transcription initiation factor TFIID subunit 5 alternativeName: Transcription initiation factor TFIID 100 kDa subunit shortName: TAF(II)100 shortName: TAFII-100 shortName: TAFII100 |
| geneName | TAF5 TAF2D |
| identifier | Q15542 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Host-virus interaction Nucleus Proteomics identification Reference proteome Repeat Transcription Transcription regulation WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960144] ENSEMBL:ENSG00000148835 TAF5 [Homo sapiens] |
| secondaryIdentifier | TAF5_HUMAN A8K5B4 B2RMR0 B7ZKJ6 Q53EM4 Q5SYD5 Q86UZ7 Q9Y4K5 |
| sequenceLength | 800 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154667] UniProt:Q15542-2 TAF5 [Homo sapiens] [ReferenceIsoform:405862] UniProt:Q15542-1 TAF5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:65543] TAF5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8960599] TAF5 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15542 TAF5 (65544)
