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Details on Person UniProt:P52657 GTF2A2
| Class:Id | ReferenceGeneProduct:65534 |
|---|---|
| _chainChangeLog | chain:1-109 added on Fri February 6 2015 |
| _displayName | UniProt:P52657 GTF2A2 |
| _timestamp | 2024-11-03 19:58:49 |
| chain | chain:1-109 |
| checksum | 938E7DC8B9982AE8 |
| comment | FUNCTION TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.SUBUNIT TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain) (PubMed:11005381). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.SUBUNIT (Microbial infection) Interacts with SV40 Large T antigen.INTERACTION Belongs to the TFIIA subunit 2 family. |
| description | recommendedName: Transcription initiation factor IIA subunit 2 alternativeName: General transcription factor IIA subunit 2 alternativeName: TFIIA p12 subunit shortName: TFIIA-12 shortName: TFIIAS alternativeName: Transcription initiation factor IIA gamma chain shortName: TFIIA-gamma |
| geneName | GTF2A2 TF2A2 |
| identifier | P52657 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Host-virus interaction Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GTF2A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988698] ENSEMBL:ENSG00000140307 GTF2A2 [Homo sapiens] |
| secondaryIdentifier | T2AG_HUMAN A8MYQ7 Q6FGB5 |
| sequenceLength | 109 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:65533] GTF2A2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P52657 GTF2A2 (65534)
