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Details on Person UniProt:P52655 GTF2A1

Class:Id	ReferenceGeneProduct:65532
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-376 added on Fri February 6 2015;chain:2-274 added on Fri February 6 2015;chain:275-376 added on Fri February 6 2015;initiator methionine:1 for 65532 removed on Fri Nov 03 2023;initiator methionine: for 65532 added on Fri Nov 03 2023;initiator methionine: for 65532 removed on Fri Aug 15 2025;initiator methionine:1 for 65532 added on Fri Aug 15 2025
_displayName	UniProt:P52655 GTF2A1
_timestamp	2025-08-15 21:34:28
chain	initiator methionine:1 chain:2-376 chain:2-274 chain:275-376
checksum	4BAE1853E7E89218
comment	FUNCTION TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.SUBUNIT TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.INTERACTION The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.SIMILARITY Belongs to the TFIIA subunit 1 family.
description	recommendedName: Transcription initiation factor IIA subunit 1 alternativeName: General transcription factor IIA subunit 1 alternativeName: TFIIAL alternativeName: Transcription initiation factor TFIIA 42 kDa subunit shortName: TFIIA-42 component recommendedName: Transcription initiation factor IIA alpha chain alternativeName: TFIIA p35 subunit /component component recommendedName: Transcription initiation factor IIA beta chain alternativeName: TFIIA p19 subunit /component
geneName	GTF2A1 TF2A1
identifier	P52655
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative initiation Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	GTF2A1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002080] ENSEMBL:ENSG00000165417 GTF2A1 [Homo sapiens]
secondaryIdentifier	TF2AA_HUMAN Q3KNQ9
sequenceLength	376
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:250995] UniProt:P52655-2 GTF2A1 [Homo sapiens] [ReferenceIsoform:404330] UniProt:P52655-1 GTF2A1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:109767] GTF2A1(1-274) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:109768] GTF2A1(275-376) [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P52655 GTF2A1 (65532)