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Details on Person UniProt:O75448 MED24
| Class:Id | ReferenceGeneProduct:65500 |
|---|---|
| _chainChangeLog | chain:1-989 added on Fri February 6 2015 |
| _displayName | UniProt:O75448 MED24 |
| _timestamp | 2024-11-03 19:57:12 |
| chain | chain:1-989 |
| checksum | CCEDE7D4E74D890C |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.INTERACTION Ubiquitous. Abundant in skeletal muscle, heart and placenta.SIMILARITY Belongs to the Mediator complex subunit 24 family. |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 24 alternativeName: Activator-recruited cofactor 100 kDa component shortName: ARC100 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 4 shortName: CRSP complex subunit 4 alternativeName: Mediator complex subunit 24 alternativeName: Thyroid hormone receptor-associated protein 4 alternativeName: Thyroid hormone receptor-associated protein complex 100 kDa component shortName: Trap100 shortName: hTRAP100 alternativeName: Vitamin D3 receptor-interacting protein complex 100 kDa component shortName: DRIP100 |
| geneName | MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100 |
| identifier | O75448 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED24 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996097] ENSEMBL:ENSG00000008838 MED24 [Homo sapiens] |
| secondaryIdentifier | MED24_HUMAN A8K4S5 B3KMR9 Q14143 Q9NNY5 |
| sequenceLength | 989 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974352] UniProt:O75448-1 MED24 [Homo sapiens] [ReferenceIsoform:8974353] UniProt:O75448-2 MED24 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:212331] MED24 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75448 MED24 (65500)
