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Details on Person UniProt:P78423 CX3CL1
| Class:Id | ReferenceGeneProduct:65400 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Sat February 7 2015;chain:25-397 added on Sat February 7 2015;chain:25- added on Sat February 7 2015 |
| _displayName | UniProt:P78423 CX3CL1 |
| _timestamp | 2024-11-03 19:54:41 |
| chain | signal peptide:1-24 chain:25-397 chain:25-339 |
| checksum | BAC71F5080DF9CA6 |
| comment | FUNCTION Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:12055230, PubMed:21829356, PubMed:23125415, PubMed:9782118, PubMed:9931005). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:12055230, PubMed:9024663, PubMed:9177350, PubMed:9782118). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (PubMed:23125415, PubMed:24789099). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (PubMed:23125415, PubMed:24789099). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099).FUNCTION The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils.FUNCTION The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.FUNCTION (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes (PubMed:27653778). The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable).SUBUNIT Monomer (PubMed:9931005). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (PubMed:23125415).SUBUNIT (Microbial infection) Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1.SUBUNIT (Microbial infection) Interacts (via N-terminus) with human cytomegalovirus (HHV-5) US28.SUBUNIT (Microbial infection) Interacts with P.falciparum (strain 3D7) CBP1 and CBP2 (via their extracellular domains); the interaction mediates the adhesion of infected erythrocytes with endothelial cells.INTERACTION Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.INDUCTION By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.PTM A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.PTM O-glycosylated with core 1 or possibly core 8 glycans.SIMILARITY Belongs to the intercrine delta family.ONLINE INFORMATION CX3CL1 entry |
| description | recommendedName: fullName evidence="17"Fractalkine alternativeName: fullName evidence="18"C-X3-C motif chemokine 1 alternativeName: fullName evidence="18"CX3C membrane-anchored chemokine alternativeName: fullName evidence="19"Neurotactin alternativeName: Small-inducible cytokine D1 component recommendedName: Processed fractalkine /component |
| geneName | CX3CL1 FKN NTT SCYD1 A-152E5.2 |
| identifier | P78423 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell adhesion Cell membrane Chemotaxis Cytokine Disulfide bond Glycoprotein Host-virus interaction Inflammatory response Membrane Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CX3CL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993993] ENSEMBL:ENSG00000006210 CX3CL1 [Homo sapiens] |
| secondaryIdentifier | X3CL1_HUMAN O00672 |
| sequenceLength | 397 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:373368] CX3CL1 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P78423 CX3CL1 (65400)
