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Details on Person UniProt:P51809 VAMP7
| Class:Id | ReferenceGeneProduct:65392 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-220 added on Sat February 7 2015;initiator methionine:1 for 65392 removed on Fri Nov 03 2023;initiator methionine: for 65392 added on Fri Nov 03 2023;initiator methionine: for 65392 removed on Fri Aug 15 2025;initiator methionine:1 for 65392 added on Fri Aug 15 2025 |
| _displayName | UniProt:P51809 VAMP7 |
| _timestamp | 2025-08-15 21:19:59 |
| chain | initiator methionine:1 chain:2-220 |
| checksum | 9C1AA5C590375CEF |
| comment | FUNCTION Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.SUBUNIT Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity). Interacts with PICALM (PubMed:23741335). Interacts with RAB21 (PubMed:25648148).INTERACTION In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).ALTERNATIVE PRODUCTS Detected in all tissues tested.MISCELLANEOUS The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.MISCELLANEOUS Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells.SIMILARITY Belongs to the synaptobrevin family.SEQUENCE CAUTION Sequence of unknown origin in the C-terminal part. |
| description | recommendedName: Vesicle-associated membrane protein 7 shortName: VAMP-7 alternativeName: Synaptobrevin-like protein 1 alternativeName: Tetanus-insensitive VAMP shortName: Ti-VAMP |
| geneName | VAMP7 SYBL1 |
| identifier | P51809 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Cytoplasmic vesicle Direct protein sequencing Endoplasmic reticulum Endosome Exocytosis Golgi apparatus Lysosome Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Signal-anchor Synapse Synaptosome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VAMP7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991648] ENSEMBL:ENSG00000124333 VAMP7 [Homo sapiens] |
| secondaryIdentifier | VAMP7_HUMAN Q53GY7 Q7Z409 Q9H4A7 |
| sequenceLength | 220 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:254064] UniProt:P51809-2 VAMP7 [Homo sapiens] [ReferenceIsoform:254065] UniProt:P51809-3 VAMP7 [Homo sapiens] [ReferenceIsoform:404300] UniProt:P51809-1 VAMP7 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:266197] VAMP7 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:376336] VAMP7 [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:376342] VAMP7 [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:376361] VAMP7 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2029047] VAMP7 [phagocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2193120] VAMP7 [late endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869135] VAMP7 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P51809 VAMP7 (65392)
