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Details on Person UniProt:O15444 CCL25
| Class:Id | ReferenceGeneProduct:65380 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-150 added on Fri February 6 2015 |
| _displayName | UniProt:O15444 CCL25 |
| _timestamp | 2024-11-03 20:13:36 |
| chain | signal peptide:1-23 chain:24-150 |
| checksum | 91D0810F137FBC7B |
| comment | FUNCTION Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.INTERACTION Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the intercrine beta (chemokine CC) family.ONLINE INFORMATION CCL25 entry |
| description | recommendedName: C-C motif chemokine 25 alternativeName: Chemokine TECK alternativeName: Small-inducible cytokine A25 alternativeName: Thymus-expressed chemokine |
| geneName | CCL25 SCYA25 TECK |
| identifier | O15444 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chemotaxis Cytokine Disulfide bond Inflammatory response Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCL25 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989420] ENSEMBL:ENSG00000131142 CCL25 [Homo sapiens] |
| secondaryIdentifier | CCL25_HUMAN A1L4J4 A6NI52 A8K9E7 B5MCA5 Q96KJ7 |
| sequenceLength | 150 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154508] UniProt:O15444-2 CCL25 [Homo sapiens] [ReferenceIsoform:401345] UniProt:O15444-1 CCL25 [Homo sapiens] [ReferenceIsoform:8965508] UniProt:O15444-3 CCL25 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:373096] CCL25 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15444 CCL25 (65380)
