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Details on Person UniProt:P78556 CCL20
| Class:Id | ReferenceGeneProduct:65370 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-96 added on Fri February 6 2015;chain:27-93 added on Fri February 6 2015;chain:27-90 added on Fri February 6 2015;chain:28-96 added on Fri February 6 2015 |
| _displayName | UniProt:P78556 CCL20 |
| _timestamp | 2024-11-03 20:09:12 |
| chain | signal peptide:1-26 chain:27-96 chain:27-93 chain:27-90 chain:28-96 |
| checksum | 1ED19EC2E1AC70AD |
| comment | FUNCTION Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11035086, PubMed:11352563, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:11352563, PubMed:9038201). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).INTERACTION Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.INDUCTION By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.PTM C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.SIMILARITY Belongs to the intercrine beta (chemokine CC) family.ONLINE INFORMATION CCL20 entry |
| description | recommendedName: C-C motif chemokine 20 alternativeName: Beta-chemokine exodus-1 alternativeName: CC chemokine LARC alternativeName: Liver and activation-regulated chemokine alternativeName: Macrophage inflammatory protein 3 alpha shortName: MIP-3-alpha alternativeName: Small-inducible cytokine A20 component recommendedName: CCL20(1-67) /component component recommendedName: CCL20(1-64) /component component recommendedName: CCL20(2-70) /component |
| geneName | CCL20 LARC MIP3A SCYA20 |
| identifier | P78556 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Antibiotic Antimicrobial Chemotaxis Cytokine Direct protein sequencing Disulfide bond Inflammatory response Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCL20 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6784989] ENSEMBL:ENSG00000115009 CCL20 [Homo sapiens] |
| secondaryIdentifier | CCL20_HUMAN Q53S51 Q99664 |
| sequenceLength | 96 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154505] UniProt:P78556-2 CCL20 [Homo sapiens] [ReferenceIsoform:404836] UniProt:P78556-1 CCL20 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:373097] CCL20(27-96) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P78556 CCL20 (65370)
