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Details on Person UniProt:P13500 CCL2
| Class:Id | ReferenceGeneProduct:65344 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-99 added on Fri February 6 2015 |
| _displayName | UniProt:P13500 CCL2 |
| _timestamp | 2024-11-03 19:50:16 |
| chain | signal peptide:1-23 chain:24-99 |
| checksum | 45EC72361435302F |
| comment | FUNCTION Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).SUBUNIT Monomer or homodimer; in equilibrium (PubMed:15033992, PubMed:8898111, PubMed:8989326, PubMed:9837883). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). Interacts with TNFAIP6 (via Link domain).INTERACTION Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477).INDUCTION Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). Up-regulated by coagulation factor Xa (F10) in PAR-1 (F2R)-dependent manner in cardiac fibroblasts and endothelial cells (PubMed:30568593, PubMed:34831181). Up-regulated by thrombin (F2) in endothelial cells (PubMed:30568593).PTM Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).PTM N-Glycosylated.POLYMORPHISM Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].SIMILARITY Belongs to the intercrine beta (chemokine CC) family.ONLINE INFORMATION CCL2 entry |
| description | recommendedName: C-C motif chemokine 2 alternativeName: HC11 alternativeName: Monocyte chemoattractant protein 1 alternativeName: Monocyte chemotactic and activating factor shortName: MCAF alternativeName: Monocyte chemotactic protein 1 shortName: MCP-1 alternativeName: Monocyte secretory protein JE alternativeName: Small-inducible cytokine A2 |
| geneName | CCL2 MCP1 SCYA2 |
| identifier | P13500 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Glycoprotein Inflammatory response Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642240] ENSEMBL:ENSG00000108691 CCL2 [Homo sapiens] |
| secondaryIdentifier | CCL2_HUMAN B2R4V3 Q9UDF3 |
| sequenceLength | 99 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:443967] CCL2 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9986317] CCL2 [secretory granule lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P13500 CCL2 (65344)
