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Details on Person UniProt:Q9H6I2 SOX17
| Class:Id | ReferenceGeneProduct:65334 |
|---|---|
| _chainChangeLog | chain:1-414 added on Fri February 6 2015 |
| _displayName | UniProt:Q9H6I2 SOX17 |
| _timestamp | 2026-02-20 23:11:38 |
| chain | chain:1-414 |
| checksum | C78D1F24BA00ECD1 |
| comment | FUNCTION Acts as a transcription regulator that binds target promoter DNA (PubMed:33952808). Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells.SUBUNIT Interacts with CTNNB1, LEF1 and TCF4.INTERACTION Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.DOMAIN The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Transcription factor SOX-17 |
| geneName | SOX17 |
| identifier | Q9H6I2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Disease variant DNA-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SOX17 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996280] ENSEMBL:ENSG00000164736 SOX17 [Homo sapiens] |
| secondaryIdentifier | SOX17_HUMAN |
| sequenceLength | 414 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5625834] SOX17 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H6I2 SOX17 (65334)
