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Details on Person UniProt:Q9UN79 SOX13
| Class:Id | ReferenceGeneProduct:65326 |
|---|---|
| _chainChangeLog | chain:1-622 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UN79 SOX13 |
| _timestamp | 2024-11-03 19:38:55 |
| chain | chain:1-622 |
| checksum | F8C102AF63128C06 |
| comment | FUNCTION Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982).SUBUNIT Homodimer; homodimerization reduces DNA binding efficiency (PubMed:10871192). Interacts with TCF7/TCF1 long isoform (via N-terminus); inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982). Interacts with HHEX (via N-terminus); abolishes the SOX13-mediated inhibition of WNT-mediated transcriptional activity via competitive inhibition of the SOX13-TCF7 complex (PubMed:20028982).INTERACTION Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level) (PubMed:10871192). Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver (PubMed:10871192, PubMed:20028982). Expressed in adipose tissue, cervix, colon, esophagus, ovary, prostate, small intestine, spleen, testicle, thymus and thyroid (PubMed:20028982).DISEASE Autoantibodies against SOX13 are present in sera from patients with type 1 diabetes.SEQUENCE CAUTION Several frameshifts. |
| description | recommendedName: Transcription factor SOX-13 alternativeName: Islet cell antigen 12 alternativeName: SRY (Sex determining region Y)-box 13 alternativeName: Type 1 diabetes autoantigen ICA12 |
| geneName | SOX13 |
| identifier | Q9UN79 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Differentiation DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SOX13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995714] ENSEMBL:ENSG00000143842 SOX13 [Homo sapiens] |
| secondaryIdentifier | SOX13_HUMAN B4E2B0 O95275 O95826 Q3KQV7 Q5SXX1 Q9UHW7 |
| sequenceLength | 622 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5627680] SOX13 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UN79 SOX13 (65326)
