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Details on Person UniProt:P56693 SOX10
| Class:Id | ReferenceGeneProduct:65320 |
|---|---|
| _chainChangeLog | chain:1-466 added on Fri February 6 2015 |
| _displayName | UniProt:P56693 SOX10 |
| _timestamp | 2024-11-03 19:54:04 |
| chain | chain:1-466 |
| checksum | FAA1EC108D4DE6A1 |
| comment | FUNCTION Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity).SUBUNIT Monomer. Interacts with ARMCX3 at the mitochondrial outer membrane surface. Interacts with PAX3 (PubMed:21965087).INTERACTION Expressed in fetal brain and in adult brain, heart, small intestine and colon.DOMAIN The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Transcription factor SOX-10 |
| geneName | SOX10 |
| identifier | P56693 |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing Cytoplasm Deafness Disease variant DNA-binding Hirschsprung disease Kallmann syndrome Membrane Mitochondrion Mitochondrion outer membrane Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Waardenburg syndrome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SOX10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996279] ENSEMBL:ENSG00000100146 SOX10 [Homo sapiens] |
| secondaryIdentifier | SOX10_HUMAN B4DV62 Q6FHW7 |
| sequenceLength | 466 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968062] UniProt:P56693-1 SOX10 [Homo sapiens] [ReferenceIsoform:8968063] UniProt:P56693-2 SOX10 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9824578] p-T240,T244-SOX10 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9824595] O-phospho-L-threonine at 244 [ModifiedResidue:9824599] O-phospho-L-threonine at 240 |
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No pathways have been reviewed or authored by UniProt:P56693 SOX10 (65320)
