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Details on Person UniProt:P14410 SI
| Class:Id | ReferenceGeneProduct:65288 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-1827 added on Sat February 7 2015;chain:2-1007 added on Sat February 7 2015;chain:1008-1827 added on Sat February 7 2015;initiator methionine:1 for 65288 removed on Fri Nov 03 2023;initiator methionine: for 65288 added on Fri Nov 03 2023;initiator methionine: for 65288 removed on Fri Aug 15 2025;initiator methionine:1 for 65288 added on Fri Aug 15 2025 |
| _displayName | UniProt:P14410 SI |
| _timestamp | 2025-08-15 21:26:47 |
| chain | initiator methionine:1 chain:2-1827 chain:2-1007 chain:1008-1827 |
| checksum | DCB93F068AEEF83E |
| comment | FUNCTION Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.CATALYTIC ACTIVITY Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action.CATALYTIC ACTIVITY Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.SUBUNIT The resulting sucrase and isomaltase subunits stay associated with one another in a complex by non-covalent linkages.INTERACTION Brush border.TISSUE SPECIFICITY Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.PTM The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.PTM Sulfated.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS There is a high degree of homology between the isomaltase and sucrase portions (41% of amino acid identity) indicating that this protein is evolved by partial gene duplication.SIMILARITY Belongs to the glycosyl hydrolase 31 family. |
| description | recommendedName: Sucrase-isomaltase, intestinal component recommendedName: Sucrase ecNumber: 3.2.1.48 /component component recommendedName: Isomaltase ecNumber: 3.2.1.10 /component |
| geneName | SI |
| identifier | P14410 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Glycosidase Hydrolase Membrane Multifunctional enzyme Phosphoprotein Proteomics identification Reference proteome Repeat Signal-anchor Sulfation Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SI |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992175] ENSEMBL:ENSG00000090402 SI [Homo sapiens] |
| secondaryIdentifier | SUIS_HUMAN A2RUC3 Q1JQ80 Q1RMC2 |
| sequenceLength | 1827 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:189035] SI(1008-1826) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:189090] SI(2-1006) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5659882] SI(2-1006) Q117R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5659901] SI(1008-1826) Q1098P [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5659913] SI(1008-1826) C1229Y [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:5659877] L-glutamine 117 replaced with L-arginine [ReplacedResidue:5659884] L-cysteine 1229 replaced with L-tyrosine [ReplacedResidue:5659902] L-glutamine 1098 replaced with L-proline |
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No pathways have been reviewed or authored by UniProt:P14410 SI (65288)
