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Details on Person UniProt:P41567 EIF1
| Class:Id | ReferenceGeneProduct:65286 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-113 added on Sat February 7 2015;initiator methionine:1 for 65286 removed on Fri Nov 03 2023;initiator methionine: for 65286 added on Fri Nov 03 2023;initiator methionine: for 65286 removed on Fri Aug 15 2025;initiator methionine:1 for 65286 added on Fri Aug 15 2025 |
| _displayName | UniProt:P41567 EIF1 |
| _timestamp | 2025-08-15 21:52:33 |
| chain | initiator methionine:1 chain:2-113 |
| checksum | A7BC7F9B53FFEB2C |
| comment | FUNCTION Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:12435632, PubMed:14600024, PubMed:9732867). Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap (PubMed:12435632, PubMed:14600024, PubMed:9732867). Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site (PubMed:14600024). Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection (PubMed:9732867). Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA (PubMed:12435632, PubMed:9732867). Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site (PubMed:29987188). EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG (PubMed:29987188). Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction (PubMed:24319994). Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon (PubMed:22813744).SUBUNIT Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF4G1; in specific 5'-UTR length and AUG context (PubMed:29987188). Interacts with EIF5; which in a mutual exclusive interaction associates either with EIF1 or with EIF2S2 on a common binding site (PubMed:22813744). Interacts with RENT2 (PubMed:11073994).INTERACTION Belongs to the SUI1 family. |
| description | recommendedName: fullName evidence="7"Eukaryotic translation initiation factor 1 shortName evidence="7"eIF1 alternativeName: A121 alternativeName: Protein translation factor SUI1 homolog alternativeName: Sui1iso1 |
| geneName | EIF1 SUI1 |
| identifier | P41567 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Initiation factor Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | EIF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002324] ENSEMBL:ENSG00000173812 EIF1 [Homo sapiens] |
| secondaryIdentifier | EIF1_HUMAN Q9UNQ9 |
| sequenceLength | 113 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:377205] EIF1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P41567 EIF1 (65286)
