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Details on Person UniProt:O43752 STX6
| Class:Id | ReferenceGeneProduct:65252 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-255 added on Sat February 7 2015;initiator methionine:1 for 65252 removed on Fri Nov 03 2023;initiator methionine: for 65252 added on Fri Nov 03 2023;initiator methionine: for 65252 removed on Fri Aug 15 2025;initiator methionine:1 for 65252 added on Fri Aug 15 2025 |
| _displayName | UniProt:O43752 STX6 |
| _timestamp | 2025-08-15 22:04:38 |
| chain | initiator methionine:1 chain:2-255 |
| checksum | CC05C025DE1FE89E |
| comment | FUNCTION SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.SUBUNIT Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (PubMed:17159904). Binds EEA1 (By similarity). Interacts with VPS45A (By similarity). Interacts with MARCHF2; the interaction promotes MARCHF2-mediated ubiquitination and degradation of CFTR (PubMed:23818989). Interacts with MARCHF3 (By similarity). Interacts with GOPC (PubMed:11384996). Interacts with BLTP3B (via C-terminal coiled-coil domain) (PubMed:20163565, PubMed:35499567). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000). Interacts with VPS13B (By similarity).INTERACTION Belongs to the syntaxin family. |
| description | recommendedName: Syntaxin-6 |
| geneName | STX6 |
| identifier | O43752 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Endosome Golgi apparatus Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | STX6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993344] ENSEMBL:ENSG00000135823 STX6 [Homo sapiens] |
| secondaryIdentifier | STX6_HUMAN B2R652 B4DR17 Q5VY08 Q6FH83 |
| sequenceLength | 255 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977220] UniProt:O43752-1 STX6 [Homo sapiens] [ReferenceIsoform:8977221] UniProt:O43752-2 STX6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:181572] STX6 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6811004] STX6 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:6811007] STX6 [trans-Golgi network membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43752 STX6 (65252)
