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Details on Person UniProt:Q15532 SS18
| Class:Id | ReferenceGeneProduct:65118 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-418 added on Fri February 6 2015;initiator methionine:1 for 65118 removed on Fri Nov 03 2023;initiator methionine: for 65118 added on Fri Nov 03 2023;initiator methionine: for 65118 removed on Fri Aug 15 2025;initiator methionine:1 for 65118 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q15532 SS18 |
| _timestamp | 2025-08-15 22:12:12 |
| chain | initiator methionine:1 chain:2-418 |
| checksum | 7E089D557538252F |
| comment | FUNCTION Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).SUBUNIT Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1. Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).INTERACTION Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.DISEASE A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).SIMILARITY Belongs to the SS18 family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Protein SSXT alternativeName: Protein SYT alternativeName: Synovial sarcoma translocated to X chromosome protein |
| geneName | SS18 SSXT SYT |
| identifier | Q15532 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Chromosomal rearrangement Nucleus Proteomics identification Proto-oncogene Reference proteome Repeat Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SS18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001460] ENSEMBL:ENSG00000141380 SS18 [Homo sapiens] |
| secondaryIdentifier | SSXT_HUMAN B0YJ95 Q16404 Q4VAX1 Q9BXC6 |
| sequenceLength | 418 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154371] UniProt:Q15532-2 SS18 [Homo sapiens] [ReferenceIsoform:405861] UniProt:Q15532-1 SS18 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9727441] SS18 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q15532 SS18 (65118)
