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Details on Person UniProt:P43307-1 SSR1
| Class:Id | ReferenceIsoform:65098 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-286 added on Fri February 6 2015 |
| _displayName | UniProt:P43307-1 SSR1 |
| _timestamp | 2025-05-21 21:08:52 |
| chain | signal peptide:1-18 chain:19-286 |
| checksum | 2C631DC0CC3EB489 |
| comment | FUNCTION TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.SUBUNIT Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma (PubMed:36697828). Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins (PubMed:22314232).INTERACTION Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.MISCELLANEOUS Seems to bind calcium.SIMILARITY Belongs to the TRAP-alpha family. |
| description | recommendedName: Translocon-associated protein subunit alpha shortName: TRAP-alpha alternativeName: Signal sequence receptor subunit alpha shortName: SSR-alpha |
| geneName | SSR1 TRAPA PSEC0262 |
| identifier | P43307 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Direct protein sequencing Endoplasmic reticulum Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SSR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642271] ENSEMBL:ENSG00000124783 SSR1 [Homo sapiens] |
| secondaryIdentifier | SSRA_HUMAN A8K685 Q53GX2 Q53H19 Q5TAM3 Q6IB43 Q8NBH9 Q96IA2 Q9TNQ8 Q9UN49 |
| sequenceLength | 286 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P43307-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P43307-1 SSR1 (65098)
