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Details on Person UniProt:P32745 SSTR3
| Class:Id | ReferenceGeneProduct:65092 |
|---|---|
| _chainChangeLog | chain:1-418 added on Fri February 6 2015 |
| _displayName | UniProt:P32745 SSTR3 |
| _timestamp | 2025-02-21 19:54:26 |
| chain | chain:1-418 |
| checksum | 1227095F801190C4 |
| comment | FUNCTION Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.SUBUNIT Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).INTERACTION Internalized into endoplasmic vesicles upon somatostatin-stimulation.TISSUE SPECIFICITY Brain, pituitary and pancreas.PTM Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: Somatostatin receptor type 3 shortName: SS-3-R shortName: SS3-R shortName: SS3R shortName: SST3 alternativeName: SSR-28 |
| geneName | SSTR3 |
| identifier | P32745 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SSTR3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997458] ENSEMBL:ENSG00000278195 SSTR3 [Homo sapiens] |
| secondaryIdentifier | SSR3_HUMAN A8K550 Q53ZR7 |
| sequenceLength | 418 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:374732] SSTR3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624095] SSTR3 [ciliary membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P32745 SSTR3 (65092)
