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Details on Person UniProt:P61011 SRP54
| Class:Id | ReferenceGeneProduct:65022 |
|---|---|
| _chainChangeLog | chain:1-504 added on Fri February 6 2015 |
| _displayName | UniProt:P61011 SRP54 |
| _timestamp | 2025-05-21 21:33:31 |
| chain | chain:1-504 |
| checksum | 7D7630A43BC5EC2C |
| comment | FUNCTION Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)SUBUNIT Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:12244299). Interacts with RNPS1 (PubMed:14729963). Interacts with the SRP receptor subunit SRPRA (PubMed:34020957).INTERACTION up-regulated during granulocytic differentiation.DOMAIN The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (PubMed:34020957). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (PubMed:34020957). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957).DOMAIN The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the GTP-binding SRP family. SRP54 subfamily.ONLINE INFORMATION Signal recognition particle entry |
| description | recommendedName: Signal recognition particle subunit SRP54 ecNumber evidence="5 7"3.6.5.4 alternativeName: fullName evidence="10"Signal recognition particle 54 kDa protein |
| geneName | SRP54 |
| identifier | P61011 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disease variant Endoplasmic reticulum GTP-binding Hydrolase Nucleotide-binding Nucleus Proteomics identification Reference proteome Ribonucleoprotein RNA-binding Signal recognition particle |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SRP54 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001459] ENSEMBL:ENSG00000100883 SRP54 [Homo sapiens] |
| secondaryIdentifier | SRP54_HUMAN B2R759 B4DUW6 P13624 |
| sequenceLength | 504 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968989] UniProt:P61011-1 SRP54 [Homo sapiens] [ReferenceIsoform:8968990] UniProt:P61011-2 SRP54 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:264977] SRP54 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P61011 SRP54 (65022)
