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Details on Person UniProt:P09132 SRP19
| Class:Id | ReferenceGeneProduct:65020 |
|---|---|
| _chainChangeLog | chain:1-144 added on Fri February 6 2015 |
| _displayName | UniProt:P09132 SRP19 |
| _timestamp | 2024-11-03 19:38:58 |
| chain | chain:1-144 |
| checksum | E25F661972338CAE |
| comment | FUNCTION Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity).SUBUNIT Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and 6 protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:12244299, PubMed:20179341). Interacts with IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with IPO8 and TNPO1 may be involved in SRP19 import into the nucleus (PubMed:11682607).INTERACTION Although the signal recognition particle complex acts in the cytoplasm, it assembles at least in part in the nucleus and/or the nucleolus. SRP19 nuclear import may be mediated by IPO8/Imp8 and TPNO1/Trn.ALTERNATIVE PRODUCTS Belongs to the SRP19 family.ONLINE INFORMATION Signal recognition particle entry |
| description | recommendedName: Signal recognition particle 19 kDa protein shortName: SRP19 |
| geneName | SRP19 |
| identifier | P09132 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Nucleus Proteomics identification Reference proteome Ribonucleoprotein RNA-binding Signal recognition particle |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SRP19 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003841] ENSEMBL:ENSG00000153037 SRP19 [Homo sapiens] |
| secondaryIdentifier | SRP19_HUMAN B2R4E9 D6RCQ5 Q05D77 Q96FG6 |
| sequenceLength | 144 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968066] UniProt:P09132-1 SRP19 [Homo sapiens] [ReferenceIsoform:8968067] UniProt:P09132-2 SRP19 [Homo sapiens] [ReferenceIsoform:8968068] UniProt:P09132-3 SRP19 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:264956] SRP19 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P09132 SRP19 (65020)
