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Details on Person UniProt:P35270 SPR
| Class:Id | ReferenceGeneProduct:64988 |
|---|---|
| _chainChangeLog | chain:1-261 added on Sat February 7 2015 |
| _displayName | UniProt:P35270 SPR |
| _timestamp | 2025-08-15 21:57:12 |
| chain | chain:1-261 |
| checksum | 9C9BF76212826F47 |
| comment | FUNCTION Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.CATALYTIC ACTIVITY L-erythro-7,8-dihydrobiopterin + NADP(+) = L-sepiapterin + NADPH + H(+)CATALYTIC ACTIVITY (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 1.1 sec(-1) with sepiapterin as substrate (PubMed:10350607). kcat is 1.1 sec(-1) with NADPH as substrate (PubMed:10350607).SUBUNIT Homodimer.SUBCELLULAR LOCATION In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sepiapterin reductase family. |
| description | recommendedName: Sepiapterin reductase shortName: SPR ecNumber evidence="3 4"1.1.1.153 |
| geneName | SPR |
| identifier | P35270 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Disease variant Dystonia NADP Oxidoreductase Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SPR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997455] ENSEMBL:ENSG00000116096 SPR [Homo sapiens] |
| secondaryIdentifier | SPRE_HUMAN A8K741 D6W5H2 Q53GI9 Q9UBB1 |
| sequenceLength | 261 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1497782] p-S213-SPR [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1497798] SPR [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:1497776] O-phospho-L-serine at 213 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35270 SPR (64988)
