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Details on Person UniProt:P09486 SPARC
| Class:Id | ReferenceGeneProduct:64986 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Fri February 6 2015;chain:18-303 added on Fri February 6 2015 |
| _displayName | UniProt:P09486 SPARC |
| _timestamp | 2024-11-03 20:12:12 |
| chain | signal peptide:1-17 chain:18-303 |
| checksum | B914599F79705945 |
| comment | FUNCTION Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.INTERACTION In or around the basement membrane.DEVELOPMENTAL STAGE Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SPARC family.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the C-terminal part.ONLINE INFORMATION Osteonectin entry |
| description | recommendedName: SPARC alternativeName: Basement-membrane protein 40 shortName: BM-40 alternativeName: Osteonectin shortName: ON alternativeName: Secreted protein acidic and rich in cysteine |
| geneName | SPARC ON |
| identifier | P09486 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Basement membrane Calcium Copper Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Metal-binding Osteogenesis imperfecta Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SPARC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958636] ENSEMBL:ENSG00000113140 SPARC [Homo sapiens] |
| secondaryIdentifier | SPRC_HUMAN D3DQH9 Q6IBK4 |
| sequenceLength | 303 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:114642] SPARC [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:114643] SPARC [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2239456] SPARC [endocytic vesicle lumen] [Homo sapiens] [EntityWithAccessionedSequence:9612283] SPARC [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P09486 SPARC (64986)
