Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P63272 SUPT4H1
| Class:Id | ReferenceGeneProduct:64906 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-117 added on Sat February 7 2015;initiator methionine:1 for 64906 removed on Fri Nov 03 2023;initiator methionine: for 64906 added on Fri Nov 03 2023;initiator methionine: for 64906 removed on Fri Aug 15 2025;initiator methionine:1 for 64906 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63272 SUPT4H1 |
| _timestamp | 2025-08-15 22:12:06 |
| chain | initiator methionine:1 chain:2-117 |
| checksum | 09EDF007501D0F03 |
| comment | FUNCTION Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10454543, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:15136722). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10199401, PubMed:10912001, PubMed:11112772). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10199401, PubMed:10912001, PubMed:11112772). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:10199401, PubMed:10912001, PubMed:11112772). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:11112772). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772).SUBUNIT Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II (Pol II); forms DNA and RNA clamps that stabilize Pol II elongation complex while maintaining the nontemplate DNA strand in the transcription bubble and nascent RNA in the exit channel. This interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1.INTERACTION Widely expressed.PTM Ubiquitinated by UBR5 when not assembled in the DSIF complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when SUPT4H1 is part of the DSIF complex.SIMILARITY Belongs to the SPT4 family. |
| description | recommendedName: Transcription elongation factor SPT4 shortName: hSPT4 alternativeName: DRB sensitivity-inducing factor 14 kDa subunit shortName: DSIF p14 alternativeName: DRB sensitivity-inducing factor small subunit shortName: DSIF small subunit |
| geneName | SUPT4H1 SPT4H SUPT4H |
| identifier | P63272 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Metal-binding Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | SUPT4H1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001456] ENSEMBL:ENSG00000213246 SUPT4H1 [Homo sapiens] |
| secondaryIdentifier | SPT4H_HUMAN B2R4X8 D3DTZ4 Q16550 Q62387 Q6ZP89 |
| sequenceLength | 117 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:64905] SUPT4H1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P63272 SUPT4H1 (64906)
