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Details on Person UniProt:P35326 SPRR2A
| Class:Id | ReferenceGeneProduct:64896 |
|---|---|
| _chainChangeLog | chain:1-72 added on Fri February 6 2015 |
| _displayName | UniProt:P35326 SPRR2A |
| _timestamp | 2024-11-03 19:58:43 |
| chain | chain:1-72 |
| checksum | 28B452D0F8B6344A |
| comment | FUNCTION Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635).INTERACTION Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen.TISSUE SPECIFICITY Expressed in intestine; selectively expressed in goblet cells.INDUCTION During squamous differentiation of epidermal keratinocytes.PTM Forms five pairs of intrachain disulfide bonds.SIMILARITY Belongs to the cornifin (SPRR) family. |
| description | recommendedName: fullName evidence="9"Small proline-rich protein 2A shortName evidence="7"SPR-2A alternativeName: fullName evidence="7"2-1 |
| geneName | SPRR2A |
| identifier | P35326 |
| isSequenceChanged | FALSE |
| keyword | Antibiotic Antimicrobial Cytoplasmic vesicle Disulfide bond Lipid-binding Proteomics identification Reference proteome Repeat Secreted |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SPRR2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992165] ENSEMBL:ENSG00000241794 SPRR2A [Homo sapiens] |
| secondaryIdentifier | SPR2A_HUMAN B2R4T3 D3DV35 Q5T529 |
| sequenceLength | 72 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6810863] SPRR2A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8934850] SPRR2A [cornified envelope] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35326 SPRR2A (64896)
