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Details on Person UniProt:Q06945 SOX4
| Class:Id | ReferenceGeneProduct:64860 |
|---|---|
| _chainChangeLog | chain:1-474 added on Fri February 6 2015 |
| _displayName | UniProt:Q06945 SOX4 |
| _timestamp | 2024-11-03 20:03:19 |
| chain | chain:1-474 |
| checksum | CB75B76ABF507A07 |
| comment | FUNCTION Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311).SUBUNIT Interacts with UBE2I (PubMed:16631117). Interacts with HDAC1; interaction inhibits the transcriptional activator activity (PubMed:16631117).INTERACTION Testis, brain, and heart.DOMAIN The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.PTM Acetylation at Lys-95 by KAT5 promotes the transcription activator activity and is required during myoblast differentiation (PubMed:26291311). Acetylation by KAT5 abolishes the interaction between SOX4 and HDAC1 and switches SOX4 into a transcriptional activator (PubMed:26291311).DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: fullName evidence="10"Transcription factor SOX-4 |
| geneName | SOX4 |
| identifier | Q06945 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Disease variant DNA-binding Intellectual disability Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SOX4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000866] ENSEMBL:ENSG00000124766 SOX4 [Homo sapiens] |
| secondaryIdentifier | SOX4_HUMAN |
| sequenceLength | 474 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5625832] SOX4 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q06945 SOX4 (64860)
