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Details on Person UniProt:Q07889 SOS1
| Class:Id | ReferenceGeneProduct:64848 |
|---|---|
| _chainChangeLog | chain:1-1333 added on Fri February 6 2015 |
| _displayName | UniProt:Q07889 SOS1 |
| _timestamp | 2025-05-21 21:39:37 |
| chain | chain:1-1333 |
| checksum | C6B99CCA11A8DE45 |
| comment | FUNCTION Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).SUBUNIT Interacts (via C-terminus) with GRB2 (via SH3 domain) (PubMed:7664271, PubMed:8493579). Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains) (PubMed:7664271). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with NCK1 and NCK2 (PubMed:10026169). Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity). Interacts (Ser-1134 and Ser-1161 phosphorylated form) with YWHAB and YWHAE (PubMed:22827337).INTERACTION Expressed in gingival tissues.PTM Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION Son of sevenless entry |
| description | recommendedName: Son of sevenless homolog 1 shortName: SOS-1 |
| geneName | SOS1 |
| identifier | Q07889 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Guanine-nucleotide releasing factor Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | SOS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998602] ENSEMBL:ENSG00000115904 SOS1 [Homo sapiens] |
| secondaryIdentifier | SOS1_HUMAN A8K2G3 B4DXG2 |
| sequenceLength | 1333 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974491] UniProt:Q07889-1 SOS1 [Homo sapiens] [ReferenceIsoform:8974492] UniProt:Q07889-2 SOS1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:64847] SOS1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:109821] p-4S-SOS1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:983559] SOS1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:109819] O-phospho-L-serine at 1132 [ModifiedResidue:109820] O-phospho-L-serine at 1167 [ModifiedResidue:112323] O-phospho-L-serine at 1193 [ModifiedResidue:112326] O-phospho-L-serine at 1178 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q07889 SOS1 (64848)
