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Details on Person SOS1 [cytosol]
Class:Id EntityWithAccessionedSequence:64847 _displayName SOS1 [cytosol] _timestamp 2016-06-10 20:11:42 compartment [Compartment:70101] cytosol endCoordinate 1333 modified [InstanceEdit:109781] Schmidt, EE, 2004-01-21 04:32:59 [InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08 [InstanceEdit:113846] Schmidt, EE, 2004-06-23 11:28:38 [InstanceEdit:1460241] Jupe, S, 2011-07-25 [InstanceEdit:2006497] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:8876264] Orlic-Milacic, Marija, 2016-06-10 name SOS1 referenceEntity [ReferenceGeneProduct:64848] UniProt:Q07889 SOS1 [Homo sapiens] species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:370544] R-HSA-64847.2 startCoordinate 1 (activeUnit) [CatalystActivity:109806] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y427-SHC1 [cytosol] [CatalystActivity:177932] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [CatalystActivity:180290] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [CatalystActivity:186837] guanyl-nucleotide exchange factor activity of PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] [CatalystActivity:208896] guanyl-nucleotide exchange factor activity of SOS1:Ras:GDP [cytosol] [CatalystActivity:210973] guanyl-nucleotide exchange factor activity of SOS-1 bound to Tie2:Grb2 [plasma membrane] [CatalystActivity:392052] guanyl-nucleotide exchange factor activity of Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] [CatalystActivity:508253] guanyl-nucleotide exchange factor activity of Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] [CatalystActivity:1433439] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane] [CatalystActivity:2424479] guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (hasCandidate) [CandidateSet:9009718] SOS1, SOS2 [cytosol] [Homo sapiens] [CandidateSet:9013168] RAC1 GEFs [cytosol] [Homo sapiens] (hasComponent) [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:109810] Crk:SOS [cytosol] [Homo sapiens] [Complex:110007] phospho-Crk:SOS [plasma membrane] [Homo sapiens] [Complex:206629] SOS1:Ras:GDP [cytosol] [Homo sapiens] [Complex:206953] SOS1:Ras:GTP [cytosol] [Homo sapiens] [Complex:210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] [Homo sapiens] [Complex:354168] GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] [Homo sapiens] [Complex:392044] pFAK:Grb2:Sos [cytosol] [Homo sapiens] [Complex:983692] BLNK:GRB2:SOS1:CIN85 [cytosol] [Homo sapiens] [Complex:8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] [Homo sapiens] (hasMember) [DefinedSet:167215] SOS [cytosol] [Homo sapiens] [CandidateSet:194849] GEFs [cytosol] [Homo sapiens] [DefinedSet:9029080] SOS1,p-Y-VAV1 [cytosol] [Homo sapiens] (input) [Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens] [Reaction:209354] Human SOS1 binds to Ras:GDP complex [Homo sapiens] [Reaction:210974] Interaction of SOS-1 to Tie2 bound Grb2 [Homo sapiens] [Reaction:354165] Interaction of SOS with GRB2 bound to FADK1 [Homo sapiens] [Reaction:392053] SOS binds Grb2 bound to pFAK:NCAM1 [Homo sapiens] [Reaction:8851859] Activated MET binds RANBP9 and SOS1 [Homo sapiens] [Reaction:9607301] Active FLT3:GRB2 binds SOS1 [Homo sapiens] [Reaction:9695845] FLT3 mutant dimers:GRB2 bind SOS1 [Homo sapiens] [Reaction:9703430] FLT3 fusions:GRB2 bind SOS1 [Homo sapiens] [Reaction:9846384] GOCAM GRB2-1 binds SOS1 [Homo sapiens] (output) [Reaction:209347] Human SOS1 dissociates from Ras:GTP complex [Homo sapiens] (updatedInstance) [_UpdateTracker:9870187] Update Tracker - [EntityWithAccessionedSequence:64847] SOS1 [cytosol] - v38:[addName] [_UpdateTracker:9871105] Update Tracker - [EntityWithAccessionedSequence:64847] SOS1 [cytosol] - v39:[modifyEndCoordinate]
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No pathways have been reviewed or authored by SOS1 [cytosol] (64847)
