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Details on Person UniProt:O00161 SNAP23

Class:IdReferenceGeneProduct:64694
_chainChangeLogchain:1-211 added on Sat February 7 2015
_displayNameUniProt:O00161 SNAP23
_timestamp2024-11-03 19:48:41
chainchain:1-211
checksumAC378E9786C3A239
commentFUNCTION Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.SUBUNIT Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).INTERACTION Mainly localized to the plasma membrane.ALTERNATIVE PRODUCTS Ubiquitous. Highest levels where found in placenta.SIMILARITY Belongs to the SNAP-25 family.
descriptionrecommendedName: Synaptosomal-associated protein 23 shortName: SNAP-23 alternativeName: Vesicle-membrane fusion protein SNAP-23
geneNameSNAP23
identifierO00161
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Alternative splicing
Cell membrane
Coiled coil
Direct protein sequencing
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Repeat
Synapse
Synaptosome
Transport
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameSNAP23
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8998007] ENSEMBL:ENSG00000092531 SNAP23 [Homo sapiens]
secondaryIdentifierSNP23_HUMAN
O00162
Q13602
Q6IAE3
sequenceLength211
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:154127] UniProt:O00161-2 SNAP23 [Homo sapiens]
[ReferenceIsoform:401084] UniProt:O00161-1 SNAP23 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:376345] SNAP23 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:6806141] SNAP23 [tertiary granule membrane] [Homo sapiens]
[EntityWithAccessionedSequence:6806157] SNAP23 [specific granule membrane] [Homo sapiens]
[EntityWithAccessionedSequence:8863923] p-S95-SNAP23 [phagocytic vesicle membrane] [Homo sapiens]
[EntityWithAccessionedSequence:8863966] SNAP23 [phagocytic vesicle membrane] [Homo sapiens]
(referenceSequence)[ModifiedResidue:8863932] O-phospho-L-serine at 95
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No pathways have been reviewed or authored by UniProt:O00161 SNAP23 (64694)
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